M2极化巨噬细胞构成卡介苗接种部位引发的寻常狼疮。
M2-Polarized Macrophages Compose Lupus Vulgaris Arising from a Bacillus Calmette-Guérin Vaccination Site.
作者信息
Sato Yota, Fujimura Taku, Furudate Sadanori, Kakizaki Aya, Iizawa Osamu, Aiba Setsuya
机构信息
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Department of Dermatology, Sendai Medical Center, Sendai, Japan.
出版信息
Case Rep Dermatol. 2016 Jul 19;8(2):202-206. doi: 10.1159/000447709. eCollection 2016 May-Aug.
Since bacillus Calmette-Guérin (BCG) is an attenuated strain of , lupus vulgaris (LV) is reported as one of the rare complications after BCG vaccination, correlating with immunosuppression in the lesional skin. In this report, we describe a case of LV arising from the BCG vaccination site 22 years after vaccination. Interestingly, in the present case, granuloma cells were composed of M2-polarized macrophages. Our case might explain the contribution of M2-polarized macrophages to the biology of LV arising from a BCG vaccination site.
由于卡介苗（BCG）是一种减毒株，寻常狼疮（LV）被报道为卡介苗接种后罕见的并发症之一，与病变皮肤中的免疫抑制相关。在本报告中，我们描述了一例接种卡介苗22年后在接种部位发生寻常狼疮的病例。有趣的是，在本病例中，肉芽肿细胞由M2极化巨噬细胞组成。我们的病例可能解释了M2极化巨噬细胞在卡介苗接种部位发生的寻常狼疮生物学过程中的作用。
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