Tajima Yutaka, Takagi Rie, Nakajima Tamiko, Kominato Yoshihiko
Legal Medicine and Molecular Genetics, Postgraduate School of Medicine, Gunma University, Maebashi, 371-8511, Japan.
Cases J. 2008 Nov 20;1(1):337. doi: 10.1186/1757-1626-1-337.
Bacillus Calmette-Guérin (BCG) is an attenuated strain of Mycobacterium bovis. Usually, systemic complications due to BCG vaccination are quite rare. However, since BCG is a live vaccine, there is still a possibility that it may cause an infection.
Hepatic granuloma was found incidentally in an asymptomatic 5-month-old infant who was found dead in his bed. The probable cause of death was asphyxia due to milk aspiration into the lungs. The granuloma was composed of epithelioid histiocytes with frequent multinucleated Langhans-type giant cells and a small number of lymphocytes.
The cause of the asymptomatic granuloma was not identified, but was considered likely due to BCG vaccination.
卡介苗（BCG）是牛分枝杆菌的减毒株。通常，卡介苗接种引起的全身并发症相当罕见。然而，由于卡介苗是一种活疫苗，仍有可能导致感染。
在一名5个月大无症状婴儿中偶然发现肝脏肉芽肿，该婴儿被发现死在床上。可能的死亡原因是牛奶误吸入肺部导致窒息。肉芽肿由上皮样组织细胞组成，有频繁的多核朗汉斯型巨细胞和少量淋巴细胞。
无症状肉芽肿的病因未明确，但认为可能是卡介苗接种所致。
