Wang Yanming, Ma Junjie, Liu Xinguang, Liu Riming, Xu Lingling, Wang Li, Cen Jiannong, Chu Xiaoxia
Department of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China; Department of Hematology, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China.
Department of Hematology, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China.
Oncol Lett. 2016 Dec;12(6):4717-4719. doi: 10.3892/ol.2016.5280. Epub 2016 Oct 18.
Acute promyelocytic leukemia (APL) is typified by t(15;17)(q22;q21), generating the promyelocytic leukemia (PML) gene at 15q22 with the retinoic acid α-receptor (RARA) gene at 17q21. The PML-RARA fusion gene is believed to play a vital role in leukemogenesis. A sizeable minority of patients with complex variants of APL have been reported. The present study reports the case of a 33-year-old male with APL carrying a potential complex translocation. The initial symptom was bleeding gums. Chromosomal analysis of the bone marrow cells revealed an atypical 17q aberration. Fluorescence hybridization further indicated that 92% of analyzed cells were positive for the PML-RARA fusion gene. The patient experienced complete remission following treatment with arsenic trioxide and chemotherapy. The atypical translocations in acute promyelocytic leukemia require further investigation.
急性早幼粒细胞白血病（APL）的典型特征是t(15;17)(q22;q21)，在15q22产生早幼粒细胞白血病（PML）基因，在17q21产生维甲酸α受体（RARA）基因。PML-RARA融合基因被认为在白血病发生中起关键作用。据报道，相当一部分APL复杂变异型患者存在这种情况。本研究报告了1例携带潜在复杂易位的33岁男性APL患者。最初症状为牙龈出血。对骨髓细胞进行染色体分析发现17号染色体存在非典型畸变。荧光杂交进一步表明，92%的分析细胞PML-RARA融合基因呈阳性。该患者经三氧化二砷和化疗后实现完全缓解。急性早幼粒细胞白血病中的非典型易位需要进一步研究。
