微同源性介导的末端连接：新成员加入团队。

Wang Hailong, Xu Xingzhi

Beijing Key Laboratory of DNA Damage Response and College of Life Sciences, Capital Normal University, Beijing, 100048 China.

Beijing Key Laboratory of DNA Damage Response and College of Life Sciences, Capital Normal University, Beijing, 100048 China ; Shenzhen University School of Medicine, Shenzhen, 518060 Guangdong China.

Cell Biosci. 2017 Jan 13;7:6. doi: 10.1186/s13578-017-0136-8. eCollection 2017.

DNA double-strand breaks (DSBs) are the most deleterious type of DNA damage in cells arising from endogenous and exogenous attacks on the genomic DNA. Timely and properly repair of DSBs is important for genomic integrity and survival. MMEJ is an error-prone repair mechanism for DSBs, which relies on exposed microhomologous sequence flanking broken junction to fix DSBs in a Ku- and ligase IV-independent manner. Recently, significant progress has been made in MMEJ mechanism study. In this review, we will summarize its biochemical activities of several newly identified MMEJ factors and their biological significance.

DNA双链断裂（DSB）是细胞中最具危害性的DNA损伤类型，其由基因组DNA受到内源性和外源性攻击引起。及时且恰当地修复DSB对于基因组完整性和细胞存活至关重要。微同源末端连接（MMEJ）是一种易出错的DSB修复机制，它依赖于断裂连接处侧翼暴露的微同源序列，以不依赖于Ku和连接酶IV的方式修复DSB。最近，MMEJ机制研究取得了重大进展。在本综述中，我们将总结几种新鉴定的MMEJ因子的生化活性及其生物学意义。