Singh Manmohan, Li Jiasong, Han Zhaolong, Raghunathan Raksha, Nair Achuth, Wu Chen, Liu Chih-Hao, Aglyamov Salavat, Twa Michael D, Larin Kirill V
Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA; Contributed equally to the present work.
Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.
Biomed Opt Express. 2016 Dec 19;8(1):349-366. doi: 10.1364/BOE.8.000349. eCollection 2017 Jan 1.
In this work we utilize optical coherence elastography (OCE) to assess the effects of UV-A/riboflavin corneal collagen crosslinking (CXL) on the mechanical anisotropy of porcine corneas at various intraocular pressures (IOP). There was a distinct meridian of increased Young's modulus in all samples, and the mechanical anisotropy increased as a function of IOP and also after CXL. The presented noncontact OCE technique was able to quantify the Young's modulus and elastic anisotropy of the cornea and their changes as a function of IOP and CXL, opening new avenues of research for evaluating the effects of CXL on corneal biomechanical properties.
在这项工作中，我们利用光学相干弹性成像技术（OCE）来评估紫外线A/核黄素角膜交联术（CXL）在不同眼压（IOP）下对猪角膜力学各向异性的影响。所有样本中都存在一个杨氏模量增加的明显子午线，并且力学各向异性随眼压升高以及CXL术后而增加。所提出的非接触式OCE技术能够量化角膜的杨氏模量和弹性各向异性及其随眼压和CXL的变化，为评估CXL对角膜生物力学特性的影响开辟了新的研究途径。
