Lingayya Rajaka, Vellakkaran Mari, Nagaiah Kommu, Tadikamalla Prabhakar Rao, Nanubolu Jagadeesh Babu
Organic and Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad-500 007, India.
Chem Commun (Camb). 2017 Feb 4;53(10):1672-1675. doi: 10.1039/c6cc09445g. Epub 2017 Jan 19.
An efficient Pd(ii)-catalyzed direct O-alkenylation of 2-arylquinazolinones with simple ketone-derived N-tosylhydrazones is reported. In this reaction, O-alkenylquinazolines were obtained in good yields, with excellent functional group tolerance. Pd-carbene migratory insertion is proposed as the key step in the reaction mechanism.
报道了一种高效的钯（II）催化2-芳基喹唑啉酮与简单酮衍生的N-甲苯磺酰腙的直接O-烯基化反应。在该反应中，以良好的产率得到了O-烯基喹唑啉，且官能团耐受性优异。钯-卡宾迁移插入被认为是反应机理中的关键步骤。
