Department of Ultrasonography, West China Second University Hospital, Sichuan University, Chengdu, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.
World J Pediatr. 2017 Jun;13(3):278-281. doi: 10.1007/s12519-017-0009-6. Epub 2017 Jan 19.
Fetal echocardiography (FECG) is a key screening tool for prenatal cardiac abnormalities. Herein, we examined the ultrasonic factors determining prenatal ultrasonic diagnosis of isolated ventricular septal defect (IVSD).
The diagnostic role of ultrasonic factors was investigated in patients in middle or late pregnancy, diagnosed with IVSD by FECG and confirmed using postnatal echocardiography.
One hundred and six patients with IVSD were enrolled; the majority had perimembranous VSD. The combined imaging mode of 2 dimentional-echocardiography (2DE) and color doppler flow imaging (CDFI) showed the highest rate (56.6%) of IVSD detection, while CDFIwas more efficient than 2DE (32.1% vs. 11.3%). The single-view mode was more efficient than multiple-view mode (75.5% vs. 24.5%). The highest efficient mode to detect IVSD was achieved using combined imaging mode on the single view of the left ventricular outflow tract view (LVOTV) (28.3%). FECG correctly classified 71.7% of fetal IVSD. There was a significant difference of accuracy rate in classifying IVSD among the three different imaging modes (χ =7.141, P<0.05). The single imaging mode of CDFIand the mode of CDFIcombined with 2DE correctly classified 75.9% and 75.0% of fetal IVSD, respectively. LVOTV was the most accurate view of fetal IVSD classification (85.2%; χ =15.782, P<0.05). There was no difference in accuracies of IVSD classification among multiple-view modes (χ =2.343, P>0.05) or between single-view mode and multiple-view mode (χ =0.32, P>0.05).
Single LVOTV in CDFIor CDFIcombined with 2DE of FECG were the most effective diagnostic modes for fetal IVSD diagnosis.
胎儿超声心动图（FECG）是产前心脏异常的重要筛查工具。在此，我们研究了确定孤立性室间隔缺损（IVSD）产前超声诊断的超声因素。
研究了经 FECG 诊断为 IVSD 并经产后超声心动图证实的中晚期妊娠患者的超声因素的诊断作用。
共纳入 106 例 IVSD 患者，多数为膜周部 VSD。二维超声心动图（2DE）联合彩色多普勒血流成像（CDFI）的联合成像模式检测 IVSD 的检出率最高（56.6%），而 CDFI 比 2DE 更有效（32.1%比 11.3%）。单视图模式比多视图模式更有效（75.5%比 24.5%）。左心室流出道（LVOTV）单视图联合成像模式检测 IVSD 的效率最高（28.3%）。FECG 正确分类了 71.7%的胎儿 IVSD。三种不同成像模式分类 IVSD 的准确率有显著差异（χ=7.141，P<0.05）。CDFI 单成像模式和 CDFI 联合 2DE 模式分别正确分类了 75.9%和 75.0%的胎儿 IVSD。LVOTV 是胎儿 IVSD 分类最准确的视图（85.2%；χ=15.782，P<0.05）。多视图模式之间（χ=2.343，P>0.05）或单视图模式与多视图模式之间（χ=0.32，P>0.05）的 IVSD 分类准确率无差异。
FECG 的 CDFI 单 LVOTV 或 CDFI 联合 2DE 是胎儿 IVSD 诊断最有效的诊断模式。
