通过基因组学探寻人类的全球迁徙历程。
Tracing the peopling of the world through genomics.
作者信息
Nielsen Rasmus, Akey Joshua M, Jakobsson Mattias, Pritchard Jonathan K, Tishkoff Sarah, Willerslev Eske
机构信息
Department of Integrative Biology, University of California, Berkeley, Berkeley, California 94720, USA.
Department of Statistics, University of California, Berkeley, Berkeley, California 942720, USA.
出版信息
Nature. 2017 Jan 18;541(7637):302-310. doi: 10.1038/nature21347.
Abstract
Advances in the sequencing and the analysis of the genomes of both modern and ancient peoples have facilitated a number of breakthroughs in our understanding of human evolutionary history. These include the discovery of interbreeding between anatomically modern humans and extinct hominins; the development of an increasingly detailed description of the complex dispersal of modern humans out of Africa and their population expansion worldwide; and the characterization of many of the genetic adaptions of humans to local environmental conditions. Our interpretation of the evolutionary history and adaptation of humans is being transformed by analyses of these new genomic data.
摘要
现代人类和古代人类基因组测序与分析的进展，推动了我们在理解人类进化史方面取得多项突破。这些突破包括发现解剖学意义上的现代人类与已灭绝的古人类之间存在杂交现象；对现代人类走出非洲及其在全球范围内的种群扩张这一复杂扩散过程的描述日益详尽；以及对人类许多适应当地环境条件的基因特征的刻画。对这些新基因组数据的分析正在改变我们对人类进化史和适应性的解读。
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