Bazer F W, Vallet J L, Harney J P, Gross T S, Thatcher W W
Department of Animal Science, University of Florida, Gainesville 32611-0701.
J Reprod Fertil Suppl. 1989;37:85-9.
Sheep conceptuses secrete a protein, oTP-1, between Days 10 and 21 of gestation which is responsible for establishment of pregnancy. oTP-1 inhibits uterine production of luteolytic amounts of PGF-2 alpha (PGF) produced in response to oestradiol and oxytocin. oTP-1 does not compete with oxytocin for binding to oxytocin receptors, but may interfere with oxytocin stimulation of the inositol phospholipid system. Pig conceptuses secrete oestrogens between Days 10 and 15 of pregnancy which are essential for establishment of pregnancy. Oestrogens, directly or indirectly, alter secretion of PGF from an endocrine direction (towards uterine vasculature) to an exocrine direction (towards the uterine lumen). PGF sequestered in the uterine lumen is unavailable to exert a luteolytic effect on the CL. Pig conceptus secretory proteins stimulate uterine production of PGF and PGE. Conceptus secretory proteins of sheep and pigs include proteins which have antiviral activity and may be considered interferons. In sheep, oTP-1 has both antiluteolytic and antiviral properties. The specific pig conceptus secretory proteins(s) possessing antiviral activity has not been established. Unlike oTP-1, however, it does not appear to possess antiluteolytic activity.
绵羊胚胎在妊娠第10至21天分泌一种蛋白质oTP - 1，它负责妊娠的建立。oTP - 1抑制子宫产生因雌二醇和催产素而产生的溶黄体量的前列腺素F - 2α（PGF）。oTP - 1不与催产素竞争结合催产素受体，但可能干扰催产素对肌醇磷脂系统的刺激。猪胚胎在妊娠第10至15天分泌雌激素，这对妊娠的建立至关重要。雌激素直接或间接地将PGF的分泌从内分泌方向（朝向子宫血管系统）改变为外分泌方向（朝向子宫腔）。滞留在子宫腔内的PGF无法对黄体发挥溶黄体作用。猪胚胎分泌蛋白刺激子宫产生PGF和PGE。绵羊和猪的胚胎分泌蛋白包括具有抗病毒活性的蛋白质，可被视为干扰素。在绵羊中，oTP - 1具有抗溶黄体和抗病毒特性。具有抗病毒活性的特定猪胚胎分泌蛋白尚未确定。然而，与oTP - 1不同，它似乎不具有抗溶黄体活性。
