Bazer F W, Simmen R C, Simmen F A
Department of Animal Science, University of Florida, Gainesville 32611.
Ann N Y Acad Sci. 1991;622:202-11. doi: 10.1111/j.1749-6632.1991.tb37863.x.
Maintenance of corpus luteum (CL) function is essential for establishment of pregnancy in mammals. Estrogens from pig conceptuses (embryo and associated membranes) initiate events that, with prolactin, redirect secretion of the uterine luteolytic hormone prostaglandin F2 alpha (PGF) from an endocrine (to uterine veins) to an exocrine (to uterine lumen) direction to prevent luteolysis. Ovine conceptuses secrete ovine trophoblast protein-1 (oTP-1), which exhibits high amino acid sequence relatedness with alpha II interferons (IFN alpha II) and inhibits synthesis of endometrial receptors for oxytocin and uterine production of luteolytic pulses of PGF. Estrogens and oTP-1 are local antiluteolytic signals to endometrium, whereas human chorionic gonadotrophin (hCG) appears to have a direct luteotrophic effect on CL. A progestational endometrium secretes proteins that serve as growth factors, transport proteins, regulatory proteins and enzymes, as well as transporting nutrients into the uterine lumen to support conceptus development.
维持黄体（CL）功能对于哺乳动物妊娠的建立至关重要。猪孕体（胚胎及相关胎膜）分泌的雌激素引发一系列事件，这些事件与催乳素共同作用，使子宫溶黄体激素前列腺素F2α（PGF）的分泌方向从内分泌（进入子宫静脉）转变为外分泌（进入子宫腔），从而防止黄体溶解。绵羊孕体分泌绵羊滋养层蛋白-1（oTP-1），它与α II干扰素（IFNα II）具有高度的氨基酸序列相似性，并抑制子宫内膜催产素受体的合成以及子宫产生PGF的溶黄体脉冲。雌激素和oTP-1是作用于子宫内膜的局部抗溶黄体信号，而人绒毛膜促性腺激素（hCG）似乎对黄体具有直接的促黄体作用。处于孕酮作用下的子宫内膜会分泌多种蛋白质，这些蛋白质可作为生长因子、转运蛋白、调节蛋白和酶，同时还能将营养物质输送到子宫腔内以支持孕体发育。
