Melki Imene, Tessandier Nicolas, Zufferey Anne, Boilard Eric
a Centre de Recherche du Centre Hospitalier Universitaire de Québec, Faculty of Medicine , Department of Infectious Diseases and Immunity, Université Laval , Quebec City , QC , Canada.
Platelets. 2017 May;28(3):214-221. doi: 10.1080/09537104.2016.1265924. Epub 2017 Jan 19.
Interest in cell-derived extracellular vesicles and their physiological and pathological implications is constantly growing. Microvesicles, also known as microparticles, are small extracellular vesicles released by cells in response to activation or apoptosis. Among the different microvesicles present in the blood of healthy individuals, platelet-derived microvesicles (PMVs) are the most abundant. Their characterization has revealed a heterogeneous cargo that includes a set of adhesion molecules. Similarly to platelets, PMVs are also involved in thrombosis through support of the coagulation cascade. The levels of circulatory PMVs are altered during several disease manifestations such as coagulation disorders, rheumatoid arthritis, systemic lupus erythematosus, cancers, cardiovascular diseases, and infections, pointing to their potential contribution to disease and their development as a biomarker. This review highlights recent findings in the field of PMV research and addresses their contribution to both healthy and diseased states.
对细胞衍生的细胞外囊泡及其生理和病理意义的兴趣持续增长。微泡，也称为微粒，是细胞在激活或凋亡时释放的小细胞外囊泡。在健康个体血液中存在的不同微泡中，血小板衍生微泡（PMV）最为丰富。对它们的表征揭示了一种异质货物，其中包括一组粘附分子。与血小板类似，PMV也通过支持凝血级联反应参与血栓形成。在几种疾病表现过程中，如凝血障碍、类风湿性关节炎、系统性红斑狼疮、癌症、心血管疾病和感染，循环PMV的水平会发生改变，这表明它们对疾病有潜在贡献，并且有可能发展成为一种生物标志物。本综述重点介绍了PMV研究领域的最新发现，并阐述了它们对健康和疾病状态的贡献。
