Yeh Hsien Chang, Gupta Kirti, Lu Ya-Hsuan, Srinivasan Abinaya, Delila Liling, Yen Nguyen Tran Hai, Nyam-Erdene Ariunjargal, Burnouf Thierry
School of Medicine, College of Medicine, Taipei Medical University, Xin-Yi Campus, Taipei City 110, Taiwan.
International Graduate Program in Medicine, College of Medicine, Taipei Medical University, Xin-Yi Campus, Taipei 110, Taiwan.
ACS Biomater Sci Eng. 2025 May 12;11(5):2601-2621. doi: 10.1021/acsbiomaterials.5c00473. Epub 2025 Apr 25.
Mitochondria are vital for energy production, metabolic regulation, and cellular signaling. Their dysfunction is strongly implicated in neurological, cardiovascular, and muscular degenerative diseases, where energy deficits and oxidative stress accelerate disease progression. Platelet extracellular vesicles (PEVs), once called "platelet dust", have emerged as promising agents for mitigating mitochondrial dysfunction. Like other extracellular vesicles (EVs), PEVs carry diverse molecular cargo and surface markers implicated in disease processes and therapeutic efficacy. Notably, they may possibly contain intact or partially functional mitochondrial components, making them tentatively attractive for targeting mitochondrial damage. Although direct research on PEVs-mediated mitochondrial rescue remains limited, current evidence suggests that PEVs can modulate diseases associated with mitochondrial dysfunction and potentially enhance mitochondrial health. This review explores the therapeutic potential of PEVs in neurodegenerative and cardiovascular disorders, highlighting their role in restoring mitochondrial health. By examining recent advancements in PEVs research, we aim to shed light on novel strategies for utilizing PEVs as therapeutic agents. Our goal is to underscore the importance of further fundamental and applied research into PEVs-based interventions, as innovative tools for combating a wide range of diseases linked to mitochondrial dysfunction.
线粒体对于能量产生、代谢调节和细胞信号传导至关重要。它们的功能障碍与神经、心血管和肌肉退行性疾病密切相关，在这些疾病中，能量不足和氧化应激会加速疾病进展。血小板细胞外囊泡（PEV），曾被称为“血小板尘埃”，已成为减轻线粒体功能障碍的有前景的药物。与其他细胞外囊泡（EV）一样，PEV携带多种与疾病过程和治疗效果相关的分子货物和表面标志物。值得注意的是，它们可能含有完整或部分功能的线粒体成分，这使得它们在靶向线粒体损伤方面具有初步吸引力。尽管关于PEV介导的线粒体拯救的直接研究仍然有限，但目前的证据表明，PEV可以调节与线粒体功能障碍相关的疾病，并有可能增强线粒体健康。这篇综述探讨了PEV在神经退行性疾病和心血管疾病中的治疗潜力，强调了它们在恢复线粒体健康方面的作用。通过研究PEV研究的最新进展，我们旨在阐明将PEV用作治疗药物的新策略。我们的目标是强调进一步开展基于PEV的干预措施的基础研究和应用研究的重要性，这些干预措施是对抗与线粒体功能障碍相关的多种疾病的创新工具。
