PHF13：参与RNA聚合酶II转录调控和共转录剪接的新因子。
PHF13: A new player involved in RNA polymerase II transcriptional regulation and co-transcriptional splicing.
作者信息
Fuchs Alisa, Torroba Marcos, Kinkley Sarah
机构信息
a Max Planck Institute for Molecular Genetics , Berlin , Germany.
出版信息
Transcription. 2017 Mar 15;8(2):106-112. doi: 10.1080/21541264.2016.1274813. Epub 2017 Jan 19.
Abstract
We recently identified PHF13 as an H3K4me2/3 chromatin reader and transcriptional co-regulator. We found that PHF13 interacts with RNAPIIS5P and PRC2 stabilizing their association with active and bivalent promoters. Furthermore, mass spectrometry analysis identified ∼50 spliceosomal proteins in PHF13s interactome. Here, we will discuss the potential role of PHF13 in RNAPII pausing and co-transcriptional splicing.
摘要
我们最近将PHF13鉴定为一种H3K4me2/3染色质阅读器和转录共调节因子。我们发现PHF13与RNAPIIS5P和PRC2相互作用，稳定它们与活性和双价启动子的关联。此外，质谱分析在PHF13的相互作用组中鉴定出约50种剪接体蛋白。在这里，我们将讨论PHF13在RNAPII暂停和共转录剪接中的潜在作用。
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