McCallie K R, Gaikwad N W, Castillo Cuadrado M E, Aleman M, Madigan J E, Stevenson D K, Bhutani V K
Division of Neonatology, Stanford University, Palo Alto, CA, USA.
Department of Nutrition and Environmental Toxicology, University of California Davis, Davis, CA, USA.
J Perinatol. 2017 May;37(5):591-595. doi: 10.1038/jp.2016.268. Epub 2017 Jan 19.
To determine the postnatal course of neurosteroid levels in relation to gender, mode of delivery and the extent of skin-to-skin (STS) contact during the first days of life in healthy term newborns.
Prospective observational study of 39 neonates in which parents recorded total duration of STS in the first 2 days and nine neurosteroids (dehydroepiandrosterone-sulfate, progesterone, pregnenolone, pregnenolone-sulfate, allopregnanolone, isopregnanolone, epipregnanolone, pregnanolone and pregnanolone-sulfate) were assayed from blood samples at birth and at 1-2 days of age.
All nine neurosteroid levels declined significantly during the first 2 days of life. Gender did not significantly affect the change in neurosteroid levels. The decline in neurosteroid levels was generally more pronounced in vaginal deliveries, and there was a trend toward a larger decline with more exposure to STS.
Ongoing studies may better characterize the role of neurosteroids and the influence of STS in more critically ill and premature neonates.
确定健康足月儿出生后最初几天神经甾体水平与性别、分娩方式及皮肤接触（STS）程度之间的关系。
对39名新生儿进行前瞻性观察研究，父母记录前2天的STS总时长，并在出生时及出生后1 - 2天采集血样检测9种神经甾体（硫酸脱氢表雄酮、孕酮、孕烯醇酮、硫酸孕烯醇酮、别孕烯醇酮、异孕烯醇酮、表孕烯醇酮、孕烷醇酮和硫酸孕烷醇酮）。
出生后最初2天内，所有9种神经甾体水平均显著下降。性别对神经甾体水平的变化无显著影响。阴道分娩时神经甾体水平的下降通常更为明显，且随着STS接触时间增加，有下降幅度更大的趋势。
正在进行的研究可能会更好地阐明神经甾体的作用以及STS对病情更危重和早产新生儿的影响。
