Department of Respiratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Respirology. 2017 Feb;22(2):251-262. doi: 10.1111/resp.12970.
The Clinical COPD Questionnaire (CCQ) is recommended by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) to evaluate health status in patients with COPD. The objective of this work was to systemically assess the reliability, validity, responsiveness and minimum clinically important difference (MCID) of the CCQ. A structured search was conducted in three databases to identify articles that evaluated the psychometric properties of the CCQ in individuals with COPD. Two investigators screened the title, abstract and full text of the articles to determine study eligibility and performed the data extraction. Quality assessment of included studies was assessed by the COSMIN (Consensus-Based Standards for the Selection of Health Measurement Instruments) checklist. Finally, 43 studies were included, over half of which had fair methodological quality. Internal consistency (reliability) of the CCQ total score ranged from 0.84 to 0.94, and test-retest reliability was 0.70-0.99. The overall CCQ had a better correlation with St George's Respiratory Questionnaire (SGRQ; from 0.71 to 0.88) and COPD Assessment Test (CAT; from 0.64 to 0.88) than modified Medical Research Council (mMRC; from 0.392 to 0.668) and forced expiratory volume in 1 s (FEV % predicted; from -0.31 to -0.68). Scores were different within GOLD stages, groups, composite events and co-morbidities. CCQ was sensitive to exacerbations, pulmonary rehabilitation and smoking cessation with the MCID of 0.4. The CCQ is a very useful and practical tool that can be used in clinical populations with good reliability, validity and responsiveness to interventions.
慢性阻塞性肺疾病临床问卷（CCQ）被全球慢性阻塞性肺疾病倡议（GOLD）推荐用于评估 COPD 患者的健康状况。本研究旨在系统评估 CCQ 的可靠性、有效性、反应性和最小临床重要差异（MCID）。在三个数据库中进行了结构化搜索，以确定评估 COPD 患者 CCQ 心理测量特性的文章。两名调查员筛选了文章的标题、摘要和全文，以确定研究的合格性，并进行了数据提取。采用共识基础健康测量仪器选择标准（COSMIN）检查表评估纳入研究的质量。最终纳入了 43 项研究，其中超过一半的研究方法质量中等。CCQ 总分的内部一致性（可靠性）范围为 0.84 至 0.94，重测信度为 0.70-0.99。总体而言，CCQ 与圣乔治呼吸问卷（SGRQ；0.71 至 0.88）和 COPD 评估测试（CAT；0.64 至 0.88）的相关性优于改良医学研究委员会（mMRC；0.392 至 0.668）和 1 秒用力呼气量（FEV %预测；-0.31 至 -0.68）。在 GOLD 分期、组别、综合事件和合并症中，评分存在差异。CCQ 对加重、肺康复和戒烟敏感，MCID 为 0.4。CCQ 是一种非常有用和实用的工具，可用于具有良好可靠性、有效性和对干预措施反应性的临床人群。
