Shibata H, Hisano T
Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University, Japan.
J Toxicol Sci. 1989 Aug;14(3):205-13. doi: 10.2131/jts.14.205.
The effect of D-galactosamine (GalN) on the blood clearance of 99mTc-phytate (99mTc-P) in rats was examined, and the blood clearance test of 99mTc-P was compared with the cases of serum transaminase and bilirubin test. Serum transaminase and bilirubin levels in rats increased dose-dependantly after GalN administration. The disappearance rate of 99mTc-P from blood decreased with the increase in dose of GalN and with the passage of time after the GalN administration. Changes of the blood clearance of 99mTc-P after GalN treatment in rats may be influenced by the disorder in the hepatocytes and the alteration of the liver reticuloendothelial system phagocytic function. The blood clearance test of 99mTc-P in rats showed a sensitive reaction for the acute hepatic dysfunction induced by GalN equally to or higher than the serum transaminase and bilirubin test.
研究了D-半乳糖胺（GalN）对大鼠体内99mTc-植酸盐（99mTc-P）血液清除率的影响，并将99mTc-P的血液清除试验与血清转氨酶和胆红素试验的情况进行了比较。给予GalN后，大鼠血清转氨酶和胆红素水平呈剂量依赖性升高。随着GalN剂量的增加以及GalN给药后时间的推移，99mTc-P从血液中的消失率降低。GalN处理后大鼠99mTc-P血液清除率的变化可能受肝细胞紊乱和肝网状内皮系统吞噬功能改变的影响。大鼠99mTc-P血液清除试验对GalN诱导的急性肝功能障碍显示出与血清转氨酶和胆红素试验相当或更高的敏感反应。
