Wu F, Wu L L, Zhu L X
Department of Otorhinolaryngology Head and Neck Surgery, The Second Affiliated Hospital, Hubei University of Science and Technology, Xianning 437100, China.
Zhonghua Zhong Liu Za Zhi. 2017 Jan 23;39(1):29-32. doi: 10.3760/cma.j.issn.0253-3766.2017.01.006.
To investigate whether neutrophil to lymphocyte ratio (NLR) in peripheral blood can be an independent prognostic factor in patients with head and neck squamous cell carcinoma (HNSCC). Clinical data of 97 HNSCC patients who received surgical treatment in our department between January 2008 and January 2012 were analyzed retrospectively. The 97 patients were divided into low NLR group (NLR≤5, =69) and high NLR group (NLR>5, =28) according to the NLR in preoperative peripheral blood. The relationships of NLR and clinicopathological features were analyzed. Kaplan-Meier method was used for univariate survival analysis and Cox proportional hazard model for multivariate survival analysis. The clinical stages were significantly different between high NLR group and low NLR group (<0.05), however, the age, gender, location, lymph node metastasis, smoking and alcohol of the two groups showed no significant differences (> 0.05 of all). Univariate survival analysis showed that smoking, lymph node metastasis, clinical stage and NLR value were risk factors for 3-year overall survival (OS) rate and relapse-free survival (RFS) rate of HNSCC patients (<0.05). The OS rate of high NLR and low NLR groups was 42.9% and 91.3%, and the RFS rate was 44.2% and 80.1%, respectively, with a statistically significant difference (<0.05 for both). Cox multivariate survival analysis showed that clinical stage and NLR were independent factors for prognostic evaluation of HNSCC patients (<0.05 for both). NLR level is significantly associated with clinical stage of HNSCC. High NLR is an independent prognostic rick factor and plays an important role in prognostic evaluation of HNSCC patients.
探讨外周血中性粒细胞与淋巴细胞比值（NLR）能否作为头颈部鳞状细胞癌（HNSCC）患者的独立预后因素。回顾性分析2008年1月至2012年1月在我科接受手术治疗的97例HNSCC患者的临床资料。根据术前外周血NLR将97例患者分为低NLR组（NLR≤5，n = 69）和高NLR组（NLR>5，n = 28）。分析NLR与临床病理特征的关系。采用Kaplan-Meier法进行单因素生存分析，Cox比例风险模型进行多因素生存分析。高NLR组与低NLR组的临床分期差异有统计学意义（P<0.05），然而，两组的年龄、性别、部位、淋巴结转移、吸烟和饮酒情况均无显著差异（均P>0.05）。单因素生存分析显示，吸烟、淋巴结转移、临床分期和NLR值是HNSCC患者3年总生存率（OS）和无复发生存率（RFS）的危险因素（P<0.05）。高NLR组和低NLR组的OS率分别为42.9%和91.3%，RFS率分别为44.2%和80.1%，差异有统计学意义（均P<0.05）。Cox多因素生存分析显示，临床分期和NLR是HNSCC患者预后评估的独立因素（均P<0.05）。NLR水平与HNSCC的临床分期显著相关。高NLR是独立的预后危险因素，在HNSCC患者的预后评估中起重要作用。
