Schmidt Felix, Zimmermann Hanna, Mikolajczak Janine, Oertel Frederike C, Pache Florence, Weinhold Maria, Schinzel Johann, Bellmann-Strobl Judith, Ruprecht Klemens, Paul Friedemann, Brandt Alexander U
NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany; Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Mult Scler Relat Disord. 2017 Jan;11:45-50. doi: 10.1016/j.msard.2016.11.008. Epub 2016 Nov 20.
Neuromyelitis optica spectrum disorders (NMOSD) are characterized by devastating optic neuritis attacks causing more structural damage and visual impairment than in multiple sclerosis (MS). The objective of this study was to compare vision-related quality of life in NMOSD and MS patients and correlate it to structural retinal damage and visual function.
Thirty-one NMOSD and 31 matched MS patients were included. Vision-related quality of life was assessed with the 39-item National Eye Institute Visual Function Questionnaire (NEI-VFQ). All patients underwent retinal optical coherence tomography and visual acuity and contrast sensitivity measurements.
Vision-related quality of life was reduced in NMOSD compared to MS patients. This difference was driven by a higher incidence of bilateral and more severe optic neuritis in the NMOSD group. Retinal thinning and visual impairment were significantly greater in the NMOSD cohort. Lower vision-related quality of life was associated with more retinal damage and reduced visual function as assessed by visual acuity and contrast sensitivity.
NMOSD-related bilateral ON-attacks cause severe structural damage and visual impairment that lead to severe loss of vision-related quality of life. The NEI-VFQ is a helpful tool to monitor vision-related quality of life in NMOSD patients.
视神经脊髓炎谱系障碍（NMOSD）的特征是严重的视神经炎发作，与多发性硬化症（MS）相比，会造成更多的结构损伤和视力损害。本研究的目的是比较NMOSD患者和MS患者与视力相关的生活质量，并将其与视网膜结构损伤和视觉功能相关联。
纳入31例NMOSD患者和31例匹配的MS患者。使用39项美国国立眼科研究所视觉功能问卷（NEI-VFQ）评估与视力相关的生活质量。所有患者均接受了视网膜光学相干断层扫描、视力和对比敏感度测量。
与MS患者相比，NMOSD患者与视力相关的生活质量降低。这种差异是由NMOSD组中双侧和更严重视神经炎的更高发病率所驱动的。NMOSD队列中的视网膜变薄和视力损害明显更严重。通过视力和对比敏感度评估，较低的与视力相关的生活质量与更多的视网膜损伤和视觉功能降低相关。
与NMOSD相关的双侧视神经炎发作会导致严重的结构损伤和视力损害，从而导致与视力相关的生活质量严重下降。NEI-VFQ是监测NMOSD患者与视力相关生活质量的有用工具。
