Song Ruitong, Huang Wenqiao, Yang Jun, Tang Xueshan, Huang Yihua, Chen Yingying, Zhao Mukun, Hu Qiuming, Du Yi
Department of Ophthalmology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Department of Ophthalmology, Wuzhou Gongren Hospital, Wuzhou, China.
Front Neurol. 2023 Sep 29;14:1265170. doi: 10.3389/fneur.2023.1265170. eCollection 2023.
Aquaporin-4 (AQP4) antibody-seropositive optic neuritis (AQP4-ON) is one of the most common types of optic neuritis in China. However, the association between AQP4-ON and vision-related quality of life (QoL) and depression remains poorly understood.
In this cross-sectional study, 57 patients with optic neuritis were evaluated for their vision-related QoL using a Chinese version of the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) and assessed for depressive symptoms using a Chinese version of the Beck Depression Inventory-II (BDI-II). Data regarding participants' age, sex, visual acuity, and the number of recurrence events were gathered. Linear regression analysis was employed to investigate the relationships between AQP4-ON and vision-related QoL, as well as depression.
Of the 57 included patients, 28 were AQP4-ON, and 29 were idiopathic optic neuritis (ION). AQP4-ON demonstrated a significant correlation with a decreased VFQ-25 composite score (Mean difference, -11.65 [95% CI, -21.61 to -1.69]; = 0.023) and an increased BDI-II score (Mean difference, 6.48 [95% CI, 0.25 to 12.71]; = 0.042) when compared to ION. The BDI-II score was correlated with the VFQ-25 composite score (Spearman ρ = -0.469; < 0.001) but not with the visual acuity in the worse-seeing eye (Spearman ρ = 0.024; = 0.860) or in the better-seeing eye (Spearman ρ = -0.039; = 0.775), bilateral severe visual impairment (Spearman ρ = 0.039; = 0.772) or the number of recurrence events (Spearman ρ = 0.184; = 0.171).
AQP4-positive optic neuritis is associated with a decline in vision-related quality of life as well as an increased likelihood of experiencing depression. It is crucial for clinicians to assess both vision-related QoL and depression in patients with AQP4-positive optic neuritis to provide patient-centered care.
水通道蛋白4（AQP4）抗体血清阳性视神经炎（AQP4-ON）是中国最常见的视神经炎类型之一。然而，AQP4-ON与视力相关生活质量（QoL）及抑郁之间的关联仍知之甚少。
在这项横断面研究中，使用中文版25项美国国立眼科研究所视觉功能问卷（VFQ-25）对57例视神经炎患者的视力相关QoL进行评估，并使用中文版贝克抑郁量表第二版（BDI-II）评估其抑郁症状。收集参与者的年龄、性别、视力及复发事件数量等数据。采用线性回归分析来研究AQP4-ON与视力相关QoL以及抑郁之间的关系。
在纳入的57例患者中，28例为AQP4-ON，29例为特发性视神经炎（ION）。与ION相比，AQP4-ON表现出与VFQ-25综合评分降低显著相关（平均差值，-11.65 [95%CI，-21.61至-1.69]；P = 0.023），且与BDI-II评分升高相关（平均差值，6.48 [95%CI，0.25至12.71]；P = 0.042）。BDI-II评分与VFQ-25综合评分相关（Spearman ρ = -0.469；P < 0.001），但与较差视力眼的视力（Spearman ρ = 0.024；P = 0.860）、较好视力眼的视力（Spearman ρ = -0.039；P = 0.775）、双侧严重视力损害（Spearman ρ = 0.039；P = 0.772）或复发事件数量（Spearman ρ = 0.184；P = 0.171）均无相关性。
AQP4阳性视神经炎与视力相关生活质量下降以及抑郁发生可能性增加有关。临床医生评估AQP4阳性视神经炎患者的视力相关QoL和抑郁情况以提供以患者为中心的护理至关重要。
