Schulman Lawrence S
Physics Department, Clarkson University, Potsdam, NY 13699-5820, USA.
J Theor Biol. 2017 Mar 21;417:61-67. doi: 10.1016/j.jtbi.2017.01.022. Epub 2017 Jan 17.
The tangled nature model of evolution (reviewed in the main text) is adapted for use in the study of antibody resistance acquired by horizontal gene transfer. Exchanges of DNA and the acquisition of resistant gene sequences are considered. For the parameters used, resistant strains rapidly proliferate and dominate, although initial intense antibiotic treatment can occasionally prevent this. Variation in genome distribution appears to be long tailed. If this is reflected in nature, the occurrence of resistant bacterial strains can be expected, as well as considerable variation in patient outcomes.
进化的缠结本质模型（正文已述）适用于研究通过水平基因转移获得的抗体抗性。考虑了DNA交换和抗性基因序列的获得。对于所使用的参数，抗性菌株迅速增殖并占据主导地位，尽管最初的强烈抗生素治疗偶尔可以阻止这种情况。基因组分布的变化似乎呈长尾状。如果这在自然界中得到体现，可以预期抗性细菌菌株的出现以及患者预后的显著差异。
