Elderly Care Unit, Belfast Health and Social Care trust, 51 Lisburn Road, Belfast BT9 7AB, UK.
Centre for Public Health, Institute of Clinical Sciences, Queens University Belfast, Block B, Grosvenor Road, Belfast BT12 6BJ, UK.
Age Ageing. 2017 May 1;46(3):529-530. doi: 10.1093/ageing/afw253.
We report a case of Pisa syndrome (PS) due to the acetylcholinesterase inhibitor donepezil which may have been precipitated by pharmacokinetic interactions with commonly used medications. PS is defined as a reversible lateral bending of the trunk with a tendency to lean to one side. This is a rare but very distressing complication with this commonly used medication which was not initially recognised, leading to increasing disability for the patient and significant carer stress. Cessation of donepezil and modulation of potential interacting medications resulted in complete resolution.
我们报告了一例由乙酰胆碱酯酶抑制剂多奈哌齐引起的 Pisa 综合征（PS）病例，这可能是由于与常用药物的药代动力学相互作用而引发的。PS 定义为躯干的可逆性侧倾，倾向于向一侧倾斜。这是一种罕见但非常令人痛苦的并发症，与这种常用药物有关，但最初并未被识别，导致患者的残疾程度不断增加，并给护理人员带来了巨大的压力。停止使用多奈哌齐并调节潜在的相互作用药物可导致完全缓解。
