From the Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Germany; and DZHK (German Center for Cardiovascular Research), Göttingen, Germany.
Circ Res. 2017 Jan 20;120(2):278-281. doi: 10.1161/CIRCRESAHA.116.310194.
Myocardial re-muscularization can be achieved by implantation of cardiomyocyte-containing grafts. Critical steps towards clinical translation of the 1 generation cardiac re-muscularization therapies include the choice of animal models with high predictive validity for therapeutic outcome in clinical trials.
心肌再肌化可以通过植入含有心肌细胞的移植物来实现。第一代心脏再肌化治疗向临床转化的关键步骤包括选择具有高预测性的临床试验治疗效果的动物模型。
