Abrogoua Danho Pascal, Békégnran César Pacôme, Gro Bi Marius, Doffou Elisée, Folquet Madeleine Amorissani
Department of Clinical Pharmacy and Therapeutics, Faculty of Pharmaceutical and Biological Sciences, Félix Houphouët-Boigny University, Abidjan, Cote d'Ivoire; Department of Clinical Pharmacology, Teaching Hospital of Cocody, Abidjan, Cote d'Ivoire.
Department of Clinical Pharmacy and Therapeutics, Faculty of Pharmaceutical and Biological Sciences, Félix Houphouët-Boigny University, Abidjan, Cote d'Ivoire.
J Basic Clin Pharm. 2016 Dec;8(1):15-19. doi: 10.4103/0976-0105.195083.
Clinical pharmacy activities in a pediatric inpatient department help to improve the management of patients clinically and economically.
To assess the relevance of pharmaceutical interventions (PIs) in a pediatric inpatient department in Abidjan (Cote d'Ivoire).
We carried out a cross-sectional, descriptive study from February to September 2014. The information collected was classified according to the classification of drug-related problems (DRPs) and PIs of the French Society of Clinical Pharmacy. The score assigned to each PI varied from PI (without direct clinical impact) to PI (vital clinical impact) as the importance of the potential clinical impact of the DRP was correlated to the severity of clinical consequences avoided by the PI. The relevance of PIs was assessed by their rate of acceptance by physicians and by the analysis of their clinical impact.
A total of 116 PIs were performed with 31% performed during medical rounds, 68.1% during patients' records analysis, and 0.1% on patient's admission. The main DRPs were related to noncompliance with recommendations (24.1%), overdose (21.1%), and underdosing (13.8%). The most important PIs were dose adjustment (31.8%), accuracy of drugs administration modalities (29.3%), and proposals of therapeutic choice (27.6%). The acceptance rate of PIs was highly significant (94.8%). The majority of PIs (67.3%) was assessed as having a significant clinical impact (PI) and 16.4% of PIs as very significant clinical impact (PI). A single PI (0.9%) was found with vital clinical impact.
PIs performed were relevant and contributed to the therapeutic optimization and the prevention of iatrogenic events in pediatric inpatients.
儿科住院部的临床药学活动有助于在临床和经济方面改善患者管理。
评估在阿比让（科特迪瓦）一家儿科住院部开展药学干预（PI）的相关性。
我们于2014年2月至9月开展了一项横断面描述性研究。收集的信息根据法国临床药学协会的药物相关问题（DRP）和PI分类进行归类。根据DRP潜在临床影响的重要性与PI避免的临床后果严重程度相关，分配给每个PI的分数从PI（无直接临床影响）到PI（关键临床影响）不等。通过医生的接受率以及对其临床影响的分析来评估PI的相关性。
共实施了116项PI，其中31%在查房期间实施，68.1%在分析患者病历期间实施，0.1%在患者入院时实施。主要的DRP与未遵循建议（24.1%）、用药过量（21.1%）和用药不足（13.8%）有关。最重要的PI是剂量调整（31.8%）、给药方式准确性（29.3%）和治疗选择建议（27.6%）。PI的接受率非常显著（94.8%）。大多数PI（67.3%）被评估为具有显著临床影响（PI），16.4%的PI具有非常显著的临床影响（PI）。仅发现一项PI（0.9%）具有关键临床影响。
所实施的PI具有相关性，有助于儿科住院患者的治疗优化和医源性事件的预防。
