Yismaw Malede Berihun, Adam Haileyesus, Engidawork Ephrem
Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia.
Department of Pediatrics, School of Medicine, College of Health Sciences, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia.
J Oncol. 2020 Mar 16;2020:6785835. doi: 10.1155/2020/6785835. eCollection 2020.
Even though medications play a major role in the cure, palliation, and inhibition of disease, they also expose patients to drug-related problems. Drug-related problems are frequent and may result in reduced quality of life, morbidity, and mortality.
The study was aimed to identify, characterize, and resolve drug-related problems in the Pediatric Hematology/Oncology ward of Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia.
A prospective observational study was conducted from 25 June to 25 October 2018 to assess DRPs on patients admitted at the pediatric hematology/oncology ward of Tikur Anbessa Specialized Hospital, which is the highest level governmental tertiary care hospital in Ethiopia. Data were obtained from patients' medical charts, physicians, patients/caregivers, pharmacists, and nurses. All the collected data were entered and analyzed using the Statistical Package for the Social Sciences version 25e. Descriptive statistics were used to represent the data.
Among the total 156 participants, DRPs were identified in 68.6% of the study subjects. Dosing problems which include dosage too low and high were the top ranking (39.3%) of all DRPs followed by needs additional therapy (27.2%) and nonadherence (14.0%). Systemic anti-infectives were the most common class of drugs involved in DRPs. Trimethoprim-sulfamethoxazole, methotrexate, vincristine, ondansetron, and metoclopramide were frequently involved in DRPs. The addition of drugs and change in drug dose were the two most proposed intervention types. Among the proposed interventions, 223 (92.15%) were fully accepted, 9 (3.72%) partially accepted, and 10 (4.13%) not accepted.
DRPs are common among Pediatric Hematology/Oncology ward patients. The hospital should develop a pediatric dosing chart for the commonly prescribed medications to prevent drug-related morbidity and mortality. The integration of clinical pharmacists can mitigate risks associated with DRPs.
尽管药物在疾病的治疗、缓解和抑制中发挥着重要作用，但它们也使患者面临与药物相关的问题。与药物相关的问题很常见，可能会导致生活质量下降、发病率和死亡率上升。
本研究旨在识别、描述和解决埃塞俄比亚亚的斯亚贝巴提库尔·安贝萨专科医院儿科血液学/肿瘤病房中与药物相关的问题。
2018年6月25日至10月25日进行了一项前瞻性观察研究，以评估提库尔·安贝萨专科医院儿科血液学/肿瘤病房收治患者的药物相关问题，该医院是埃塞俄比亚最高级别的政府三级护理医院。数据来自患者病历、医生、患者/护理人员、药剂师和护士。所有收集的数据均使用社会科学统计软件包第25版进行录入和分析。描述性统计用于呈现数据。
在总共156名参与者中，68.6%的研究对象被识别出存在药物相关问题。包括剂量过低和过高的给药问题在所有药物相关问题中排名第一（39.3%），其次是需要额外治疗（27.2%）和不依从（14.0%）。全身用抗感染药物是药物相关问题中最常涉及的药物类别。复方磺胺甲恶唑、甲氨蝶呤、长春新碱、昂丹司琼和甲氧氯普胺经常与药物相关问题有关。增加药物和改变药物剂量是最常提出的两种干预类型。在提出的干预措施中，223项（92.15%）被完全接受，9项（3.72%）部分接受，10项（4.13%）未被接受。
药物相关问题在儿科血液学/肿瘤病房患者中很常见。医院应制定常用处方药的儿科剂量表，以预防与药物相关的发病率和死亡率。临床药师的融入可以降低与药物相关问题相关的风险。
