Eder Piotr, Stawczyk-Eder Kamila, Korybalska Katarzyna, Czepulis Natasza, Luczak Joanna, Lykowska-Szuber Liliana, Krela-Kazmierczak Iwona, Linke Krzysztof, Witowski Janusz
Piotr Eder, Kamila Stawczyk-Eder, Liliana Lykowska-Szuber, Iwona Krela-Kazmierczak, Krzysztof Linke, Department of Gastroenterology, Human Nutrition and Internal Diseases, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
World J Gastroenterol. 2017 Jan 7;23(1):135-140. doi: 10.3748/wjg.v23.i1.135.
To evaluate whether repeated serum measurements of trefoil factor-3 (TFF-3) can reliably reflect mucosal healing (MH) in Crohn's disease (CD) patients treated with anti-tumor necrosis factor-α (anti-TNF-α) antibodies.
Serum TFF-3 was measured before and after anti-TNF-α induction therapy in 30 CD patients. The results were related to clinical, biochemical and endoscopic parameters. MH was defined as a ≥ 50% decrease in Simple Endoscopic Score for Crohn's disease (SES-CD).
SES-CD correlated significantly with CD clinical activity and several standard biochemical parameters (albumin, leukocyte and platelet counts, C-reactive protein, erythrocyte sedimentation rate, fibrinogen). In contrast, SES-CD did not correlate with TFF-3 ( = 0.54). Moreover, TFF-3 levels did not change significantly after therapy irrespectively of whether the patients achieved MH or not. Likewise, TFF-3 did not correlate with changes in fecal calprotectin, which has been proposed as another biochemical marker of mucosal damage in CD.
Serum TFF-3 is not a convenient and reliable surrogate marker of MH during therapy with TNF-α antagonists in CD.
评估重复检测血清三叶因子3（TFF-3）能否可靠反映接受抗肿瘤坏死因子-α（抗TNF-α）抗体治疗的克罗恩病（CD）患者的黏膜愈合（MH）情况。
检测30例CD患者抗TNF-α诱导治疗前后的血清TFF-3水平。结果与临床、生化及内镜参数相关。MH定义为克罗恩病简易内镜评分（SES-CD）下降≥50%。
SES-CD与CD临床活动度及多项标准生化参数（白蛋白、白细胞及血小板计数、C反应蛋白、红细胞沉降率、纤维蛋白原）显著相关。相比之下，SES-CD与TFF-3不相关（r = 0.54）。此外，无论患者是否实现MH，治疗后TFF-3水平均无显著变化。同样，TFF-3与粪便钙卫蛋白的变化也不相关，粪便钙卫蛋白被认为是CD黏膜损伤的另一个生化标志物。
在CD患者使用TNF-α拮抗剂治疗期间，血清TFF-3并非方便可靠的MH替代标志物。
