Li Qiang, Yu Zongxue, Wang Jinjun, Chen Xiao, Li Lin
Department of Vascular Surgery, The Affiliated Qingdao Hiser Hospital of Qingdao University, Qingdao, Shandong 266033, P.R. China.
Department of Internal Medicine, The Third People's Hospital of Qingdao, Qingdao, Shandong 266033, P.R. China.
Exp Ther Med. 2016 Dec;12(6):3545-3548. doi: 10.3892/etm.2016.3812. Epub 2016 Oct 18.
The aim of the present study was to observe the long-term prognostic value of early interventional therapy for lower extremity deep venous thrombosis (LDVT). In total, 85 patients diagnosed with LDVT for the first time were consecutively selected (identified course of disease was <3 months), and were divided into the control group with 43 cases and the observation group with 42 cases according to different therapeutic methods. The control group received anticoagulation therapy and thrombolysis, or integrated surgical thrombectomy, a conventional open operation, while the observation group received comprehensive treatment, combining endovascular catheter-directed thrombolysis and thrombectomy. The therapeutic effects were compared. After treatment, the differences in circumference of the thigh and shank between the affected and unaffected extremities, and vein dysfunction score of the two groups were decreased compared with before treatment. In addition, the above indexes of the observation group were significantly lower than in the control group (P<0.05). The clinical effective rate and effective extent of the observation group were higher than those of the control group, and the differences were statistically significant (P<0.05). The occurrence rate of post-thrombotic syndrome in the observation group was lower than that of the control group, and there was no difference in comparison of grading. The recurrence rate and restenosis rate of the observation group were lower than in the control group, while the patency rate of the observation group was higher than that of the control group, and the differences were statistically significant (P<0.05). In conclusion, early catheter-directed invention of thrombolysis with thrombectomy for LDVT has good clinical effect in the short-term and long-term.
本研究的目的是观察早期介入治疗对下肢深静脉血栓形成（LDVT）的长期预后价值。总共连续选取85例首次诊断为LDVT的患者（确诊病程<3个月），并根据不同治疗方法分为对照组43例和观察组42例。对照组接受抗凝治疗和溶栓治疗，或综合手术取栓，即传统的开放手术，而观察组接受综合治疗，将血管内导管直接溶栓和取栓相结合。比较两组的治疗效果。治疗后，两组患侧与健侧大腿和小腿周长的差异以及静脉功能障碍评分均较治疗前降低。此外，观察组的上述指标明显低于对照组（P<0.05）。观察组的临床有效率和有效程度均高于对照组，差异有统计学意义（P<0.05）。观察组血栓形成后综合征的发生率低于对照组，分级比较无差异。观察组的复发率和再狭窄率低于对照组，而观察组的通畅率高于对照组，差异有统计学意义（P<0.05）。综上所述，早期导管直接介入溶栓联合取栓治疗LDVT在短期和长期均具有良好的临床效果。
