Department of Biomechatronic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, South Korea.
Department of Food Science and Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, South Korea.
J Biomed Mater Res B Appl Biomater. 2018 Jan;106(1):444-459. doi: 10.1002/jbm.b.33826. Epub 2017 Jan 20.
The purpose of 3D bioprinting technology is to design and create functional 3D tissues or organs in situ for in vivo applications. 3D cell-printing, or additive biomanufacturing, allows the selection of biomaterials and cells (bioink), and the fabrication of cell-laden structures in high resolution. 3D cell-printed structures have also been used for applications such as research models, drug delivery and discovery, and toxicology. Recently, numerous attempts have been made to fabricate tissues and organs by using various 3D printing techniques. However, challenges such as vascularization are yet to be solved. This article reviews the most commonly used 3D cell-printing techniques with their advantages and drawbacks. Furthermore, up-to-date achievements of 3D bioprinting in in vivo applications are introduced, and prospects for the future of 3D cell-printing technology are discussed. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 444-459, 2018.
3D 生物打印技术的目的是设计和创建功能性 3D 组织或器官，用于体内应用。3D 细胞打印，或添加剂生物制造，允许选择生物材料和细胞（生物墨水），并以高分辨率制造细胞负载结构。3D 细胞打印结构也已用于研究模型、药物输送和发现以及毒理学等应用。最近，人们已经尝试使用各种 3D 打印技术来制造组织和器官。然而，血管化等挑战仍有待解决。本文综述了最常用的 3D 细胞打印技术及其优缺点。此外，还介绍了 3D 生物打印在体内应用中的最新成果，并讨论了 3D 细胞打印技术的未来前景。© 2017 威利父子公司。J 生物医学材料研究部分 B：应用生物材料，106B:444-459,2018.
