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药物递送与再生医学整合的进展：创新、挑战与未来前沿。

Advances in Drug Delivery Integrated with Regenerative Medicine: Innovations, Challenges, and Future Frontiers.

作者信息

Rasekh Manoochehr, Arshad Muhammad Sohail, Ahmad Zeeshan

机构信息

College of Engineering, Design and Physical Sciences, Brunel University of London, Uxbridge UB8 3PH, UK.

Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan.

出版信息

Pharmaceutics. 2025 Apr 1;17(4):456. doi: 10.3390/pharmaceutics17040456.

DOI:10.3390/pharmaceutics17040456
PMID:40284451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12030587/
Abstract

Advances in drug delivery systems adapted with regenerative medicine have transformed healthcare by introducing innovative strategies to treat (and repair in many instances) disease-impacted regions of the human body. This review provides a comprehensive analysis of the latest developments and challenges in integrating drug delivery technologies with regenerative medicine. Recent advances in drug delivery technologies, including the design of biomaterials, localized delivery techniques, and controlled release systems guided by mathematical models, are explored to illustrate their role in enhancing therapeutic precision and efficacy. Additionally, regenerative medicine approaches are analyzed, with a focus on extracellular matrix components, stem cell-based therapies, and emerging strategies for organ regeneration in both soft and hard tissue and in vitro model engineering. In particular, the review also discusses the applications of cellular components, including stem cells, immune cells, endothelial cells, and specialized cells such as chondrocytes and osteoblasts, and highlights advancements in cell delivery methods and cell-cell interaction modulation. In addition, future directions and pivotal trends emphasizing the importance of interdisciplinary collaboration and cutting-edge innovations are provided to address successful therapeutic outcomes in regenerative medicine.

摘要

与再生医学相结合的药物递送系统取得的进展，通过引入创新策略来治疗（在许多情况下还包括修复）人体受疾病影响的区域，从而改变了医疗保健行业。本综述全面分析了将药物递送技术与再生医学相结合的最新进展和挑战。探讨了药物递送技术的最新进展，包括生物材料的设计、局部递送技术以及由数学模型指导的控释系统，以阐明它们在提高治疗精度和疗效方面的作用。此外，还分析了再生医学方法，重点关注细胞外基质成分、基于干细胞的疗法，以及软组织和硬组织器官再生及体外模型工程的新兴策略。特别是，该综述还讨论了细胞成分的应用，包括干细胞、免疫细胞、内皮细胞以及软骨细胞和成骨细胞等特殊细胞，并强调了细胞递送方法和细胞间相互作用调节方面的进展。此外，还提供了强调跨学科合作和前沿创新重要性的未来方向和关键趋势，以实现再生医学的成功治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba0/12030587/893f5a15d4a2/pharmaceutics-17-00456-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba0/12030587/fd584bb885d4/pharmaceutics-17-00456-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba0/12030587/20f36a807f9c/pharmaceutics-17-00456-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba0/12030587/d0d1c40c4748/pharmaceutics-17-00456-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba0/12030587/3162aa8c95a9/pharmaceutics-17-00456-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba0/12030587/1f30a1586914/pharmaceutics-17-00456-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba0/12030587/f12a771cf023/pharmaceutics-17-00456-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba0/12030587/0204bfc7ca81/pharmaceutics-17-00456-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba0/12030587/455f8b7a03a1/pharmaceutics-17-00456-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba0/12030587/bb141dbce33c/pharmaceutics-17-00456-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba0/12030587/893f5a15d4a2/pharmaceutics-17-00456-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba0/12030587/fd584bb885d4/pharmaceutics-17-00456-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba0/12030587/20f36a807f9c/pharmaceutics-17-00456-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba0/12030587/d0d1c40c4748/pharmaceutics-17-00456-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba0/12030587/3162aa8c95a9/pharmaceutics-17-00456-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba0/12030587/1f30a1586914/pharmaceutics-17-00456-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba0/12030587/f12a771cf023/pharmaceutics-17-00456-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba0/12030587/0204bfc7ca81/pharmaceutics-17-00456-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba0/12030587/455f8b7a03a1/pharmaceutics-17-00456-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba0/12030587/bb141dbce33c/pharmaceutics-17-00456-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ba0/12030587/893f5a15d4a2/pharmaceutics-17-00456-g010.jpg

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