Okuda M, Ohi Y, Utsunomiya H, Kurata M, Konishi K, Muneyuki M
Masui. 1989 Aug;38(8):1036-41.
Effects of continuous prostaglandin E1 (PGE1) infusion 0.03 micrograms.kg-1.min-1 on hemodynamics, body temperature and urine output during cardiopulmonary bypass (CPB) were studied. Systemic vascular resistance was kept significantly lower in PGE1 administration group than control group. Differences between core and peripheral temperature decreased faster in the PGE1 administration group than the control group. Mean arterial pressure was stable at 40mmHg during CPB in the PGE1 group and 60mmHg in the control group. However, there were no significant differences in urine output between the PGE1 administration group (10.8ml.kg-1.h-1) and the control group (9.4ml.kg-1.h-1). This study indicates that continuous PGE1 infusion (0.03 micrograms.kg-1.min-1) is a method of choice for vasodilation and improvement of peripheral perfusion during hypothermia of CPB.
研究了持续输注前列腺素E1（PGE1）0.03微克·千克-1·分钟-1对体外循环（CPB）期间血流动力学、体温和尿量的影响。PGE1给药组的全身血管阻力显著低于对照组。PGE1给药组核心温度与外周温度之间的差异比对照组下降得更快。PGE1组CPB期间平均动脉压稳定在40mmHg，对照组为60mmHg。然而，PGE1给药组（10.8毫升·千克-1·小时-1）与对照组（9.4毫升·千克-1·小时-1）之间的尿量没有显著差异。本研究表明，持续输注PGE1（0.03微克·千克-1·分钟-1）是CPB低温期间血管扩张和改善外周灌注的一种选择方法。
