Hirano M
Masui. 1989 Aug;38(8):992-9.
Effects of verapamil on pulmonary ventilation-blood flow (VA/Q) distribution were studied in ten adult mongrel dogs weighing 12.5 +/- 0.8kg (mean +/- SE) by use of the multiple-inert-gas elimination method. VA/Q distributions were almost normal during control period (mean Q = 1.22, Log SD = 0.11). Under hypoxic challenge, blood flow distribution in low VA/Q area increased (mean Q = 0.68, Log SD = 0.50), and verapamil exaggerated this VA/Q inequality (mean Q = 0.53, Log SD = 0.67). However, four dogs showed increase in PaO2 and six showed decrease in PaO2. In the group of dogs with increased PaO2, CI increased significantly (P less than 0.05). In spite of the worse VA/Q distribution, PaO2 was not always decreased by verapamil infusion. This suggests that decrease in PaO2 is prevented by increased CI. Clinically, therefore, it is necessary to observe carefully the pulmonary blood flow when verapamil is to be administered in low cardiac output cases.
采用多惰性气体清除法，对10只体重为12.5±0.8kg（平均±标准误）的成年杂种犬进行了维拉帕米对肺通气-血流（VA/Q）分布影响的研究。在对照期，VA/Q分布基本正常（平均Q = 1.22，对数标准差 = 0.11）。在低氧刺激下，低VA/Q区域的血流分布增加（平均Q = 0.68，对数标准差 = 0.50），而维拉帕米加剧了这种VA/Q不均（平均Q = 0.53，对数标准差 = 0.67）。然而，4只犬的动脉血氧分压（PaO2）升高，6只犬的PaO2降低。在PaO2升高的犬组中，心脏指数（CI）显著增加（P < 0.05）。尽管VA/Q分布更差，但输注维拉帕米并不总是导致PaO2降低。这表明CI升高可防止PaO2降低。因此，临床上在低心输出量病例中使用维拉帕米时，有必要仔细观察肺血流情况。
