头孢特仑新戊酯儿科临床研究

[A clinical study on cefteram pivoxil in pediatrics].

作者信息

Satoh Y, Ishikawa K, Iwata S, Akita H, Sunakawa K

机构信息

Department of Pediatrics, Ohta General Hospital.

出版信息

Jpn J Antibiot. 1989 Aug;42(8):1780-90.

PMID:2810741

Abstract

Clinical evaluations of cefteram pivoxil (CFTM-PI, T-2588) were carried out. The obtained results are summarized as follows. 1. Clinical responses to CFTM-PI of 39 patients with pediatric infections were excellent in 16, good in 21, fair in 1 and poor in 1. The overall efficacy rate was 94.9%. 2. Bacteriologically, eradication rates for 39 isolates presumed to be pathogens were evaluated. The eradication rates obtained were 94.1% in 17 strains of Gram-positive cocci, 90.9% in 22 strains of Gram-negative rods. 3. Side effects observed were diarrhea in 2 patients, diarrhea and abdominal pain in 1, erythema and edema in 1. The incidence was 8.7%. An abnormal value found in clinical laboratory tests was eosinophilia in 1 patient. The results suggested that CFTM-PI might be a very useful and safe drug for the treatment of pediatric infections.

摘要

进行了头孢特仑新戊酯（CFTM-PI，T-2588）的临床评估。所得结果总结如下。1. 39例儿科感染患者使用CFTM-PI后的临床反应中，16例为优，21例为良，1例为中，1例为差。总有效率为94.9%。2. 从细菌学角度评估了39株推测为病原体的菌株的根除率。17株革兰氏阳性球菌的根除率为94.1%，22株革兰氏阴性杆菌的根除率为90.9%。3. 观察到的副作用为：2例腹泻，1例腹泻伴腹痛，1例红斑和水肿。发生率为8.7%。临床实验室检查中发现的异常值为1例嗜酸性粒细胞增多。结果表明，CFTM-PI可能是治疗儿科感染非常有用且安全的药物。