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预测急性下腰痛患者的恢复情况:一种临床预测模型。

Predicting recovery in patients with acute low back pain: A Clinical Prediction Model.

作者信息

da Silva T, Macaskill P, Mills K, Maher C, Williams C, Lin C, Hancock M J

机构信息

Department of Health Professions, Macquarie University, Sydney, Australia.

Sydney Medical School, The University of Sydney, Australia.

出版信息

Eur J Pain. 2017 Apr;21(4):716-726. doi: 10.1002/ejp.976. Epub 2017 Jan 20.

Abstract

BACKGROUND

There is substantial variability in the prognosis of acute low back pain (LBP). The ability to identify the probability of individual patients recovering by key time points would be valuable in making informed decisions about the amount and type of treatment to provide. Predicting recovery based on presentation 1-week after initially seeking care is clinically important and may be more accurate than predictions made at initial presentation. The aim of this study was to predict the probability of recovery at 1-week, 1-month and 3-months after 1-week review in patients who still have LBP 1-week after initially seeking care.

METHODS

The study sample comprised 1070 patients with acute LBP, with a pain score of ≥2 1-week after initially seeking care. The primary outcome measure was days to recovery from pain. Ten potential prognostic factors were considered for inclusion in a multivariable Cox regression model.

RESULTS

The final model included duration of current episode, number of previous episodes, depressive symptoms, intensity of pain at 1-week, and change in pain over the first week after seeking care. Depending on values of the predictor variables, the probability of recovery at 1-week, 1-month and 3-months after 1-week review ranged from 4% to 59%, 19% to 91% and 30% to 97%, respectively. The model had good discrimination (C = 0.758) and calibration.

CONCLUSIONS

This study found that a model based on five easily collected variables could predict the probability of recovery at key time points in people who still have LBP 1-week after seeking care.

SIGNIFICANCE

A clinical prediction model based on five easily collected variables was able to predict the likelihood of recovery from an episode of acute LBP at three key time points. The model had good discrimination (C = 0.758) and calibration.

摘要

背景

急性腰痛(LBP)的预后存在很大差异。在对提供的治疗量和类型做出明智决策时,确定个体患者在关键时间点康复的概率很有价值。基于首次就诊1周后的表现预测康复情况在临床上很重要,可能比在初次就诊时做出的预测更准确。本研究的目的是预测在初次就诊1周后仍有腰痛的患者在1周复查后1周、1个月和3个月时康复的概率。

方法

研究样本包括1070例急性腰痛患者,他们在初次就诊1周后的疼痛评分为≥2分。主要结局指标是疼痛恢复的天数。考虑将10个潜在的预后因素纳入多变量Cox回归模型。

结果

最终模型包括当前发作的持续时间、既往发作次数、抑郁症状、1周时的疼痛强度以及就诊后第一周内疼痛的变化。根据预测变量的值,1周复查后1周、1个月和3个月时康复的概率分别为4%至59%、19%至91%和30%至97%。该模型具有良好的区分度(C = 0.758)和校准度。

结论

本研究发现,基于五个易于收集的变量的模型可以预测在就诊1周后仍有腰痛的患者在关键时间点康复的概率。

意义

基于五个易于收集的变量的临床预测模型能够预测急性腰痛发作在三个关键时间点康复的可能性。该模型具有良好的区分度(C = 0.758)和校准度。

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