孤儿型核糖开关揭示了细菌中的胍基调控。

An Orphan Riboswitch Unveils Guanidine Regulation in Bacteria.

机构信息

Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.

出版信息

Mol Cell. 2017 Jan 19;65(2):205-206. doi: 10.1016/j.molcel.2017.01.001.

DOI:10.1016/j.molcel.2017.01.001

Abstract

In this issue, Nelson and colleagues (2017) determined that guanidine, the prevalent protein denaturant, is the long-lost ligand sensed by the ykkC class of riboswitches, and identified that members of its regulon are involved in guanidine detoxification and export.

摘要

在本期中，Nelson 及其同事（2017 年）确定胍，这种常见的蛋白质变性剂，是 ykkC 类核糖体开关感知的长期缺失配体，并确定其调控基因参与胍解毒和输出。