Al-U'datt Doa'a G F, Al-Husein Belal A A, Qasaimeh Ghazi Raji
Department of Pharmacology and Physiology, Faculty of Medicine, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.
Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
Biomed Pharmacother. 2017 Apr;88:194-202. doi: 10.1016/j.biopha.2017.01.045. Epub 2017 Jan 17.
Melanoma is the third highest rated cancer in prevalence. Surgery, radiotherapy and targeted/biological therapies in addition to chemotherapy are available options for management of this cancer. Met is an appealing target for management of this type of cancer, since it targets many cancer vital processors, such as angiogenesis, cell growth, scattering and differentiation. In this review, we provide an overview about pathway abnormalities associated with melanoma. We also provide a summary about the events involved in Met signaling and related signaling molecules. We also show the evidence of the importance of Met signaling pathway as a target in cancer management. We also summarize clinical evidence about the use of Met signaling in management of cancer and summarize available trials related to targeting Met in other cancers.
黑色素瘤是发病率排名第三的癌症。除化疗外，手术、放疗以及靶向/生物疗法都是治疗这种癌症的可行选择。Met是治疗这类癌症的一个有吸引力的靶点，因为它作用于许多癌症关键进程，如血管生成、细胞生长、扩散和分化。在本综述中，我们概述了与黑色素瘤相关的通路异常。我们还总结了Met信号传导及相关信号分子所涉及的事件。我们也展示了Met信号通路作为癌症治疗靶点的重要性的证据。我们还总结了关于在癌症治疗中使用Met信号传导的临床证据，并总结了与在其他癌症中靶向Met相关的现有试验。
