Hayakawa K, Arai M, Niibe H, Tamura M
Dept. of Radiology, School of Med. Gunma Univ.
Gan No Rinsho. 1989 Sep;35(11):1247-54.
For the past twenty years, 85 adult patients with cerebral glioblastoma were treated with postoperative radiation therapy (RT). Hypofractionated RT (5 Gy twice a week) was performed in 31 patients. The survival rate of the hypofractionated RT was superior to the conventionally fractionated RT, especially in the patients involved mainly in the frontal lobe. In the hypofractionation group, misonidazole proved of benefit to the survival. In future, hyperfractionation of RT seems reasonable to be explored for improving CNS tolerance.
在过去的二十年中，85例成年脑胶质母细胞瘤患者接受了术后放射治疗（RT）。31例患者采用了超分割放疗（每周两次，每次5 Gy）。超分割放疗的生存率优于常规分割放疗，尤其是主要累及额叶的患者。在超分割放疗组中，甲硝唑对生存有益。未来，探索放疗的加速超分割似乎对提高中枢神经系统耐受性是合理的。
