He Chang, Wang Xianyu, Thai Phong, Mueller Jochen F, Gallen Christie, Li Yan, Baduel Christine
Entox, Queensland Alliance for Environmental Health Science, The University of Queensland, Brisbane, Australia.
Entox, Queensland Alliance for Environmental Health Science, The University of Queensland, Brisbane, Australia.
Talanta. 2017 Mar 1;164:503-510. doi: 10.1016/j.talanta.2016.10.108. Epub 2016 Nov 17.
Flame retardants are associated to numerous adverse health effects, can accumulate in humans and have been used intensively worldwide. Recently, dust has been identified as a major human exposure route for flame retardants. The aim of this study was to develop a multi-residue method using a two-step SPE purification. It enabled us to effectively limit co-extracted matrix/interferets and therefore a simultaneous analysis of brominated and organophosphate flame retardants for indoor dust was achieved. The optimized method was validated according to standard protocol and achieved good accuracy and reproducibility (percent error ranged from -29% to 28%). Standard Reference Material (SRM) for dust was also analysed, and good agreement was found with reported brominated and organophosphate flame retardants (OPFRs) concentrations. The applicability of the validated method was demonstrated by the analysis of ten indoor dust samples from ten Australian homes. Overall 89% of the analytes were detected in these samples. The average concentrations of ∑OPFRs and ∑PBDEs in those samples were 41 and 3.6μg/g, respectively. Tris(2-butoxyethyl) phosphate and tris(2-chloroisopropyl) phosphate were the most abundant OPFRs, accounting for 57-92% ∑OPFRs, while decabromodiphenyl ether dominated the Polybrominated diphenyl ethers (PBDE) congeners contributing between 71-94% to the ∑PBDEs.
阻燃剂与众多不良健康影响相关，可在人体中蓄积，且在全球范围内被广泛使用。最近，灰尘已被确定为人类接触阻燃剂的主要途径。本研究的目的是开发一种采用两步固相萃取净化的多残留方法。该方法使我们能够有效限制共萃取的基质/干扰物，从而实现对室内灰尘中溴化阻燃剂和有机磷酸酯阻燃剂的同时分析。根据标准方案对优化后的方法进行了验证，该方法具有良好的准确性和重现性（百分误差范围为-29%至28%）。还对灰尘标准参考物质（SRM）进行了分析，发现其溴化阻燃剂和有机磷酸酯阻燃剂（OPFRs）浓度与报道值吻合良好。通过对来自十个澳大利亚家庭的十个室内灰尘样本的分析，证明了该验证方法的适用性。总体而言，这些样本中89%的分析物被检测到。这些样本中∑OPFRs和∑PBDEs的平均浓度分别为41μg/g和3.6μg/g。磷酸三（2-丁氧基乙基）酯和磷酸三（2-氯异丙基）酯是含量最高的OPFRs，占∑OPFRs的57-92%，而十溴二苯醚在多溴二苯醚（PBDE）同系物中占主导地位，占∑PBDEs的71-94%。
