Sharda N, Chakravarti R N
Department of Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Jpn J Exp Med. 1989 Jun;59(3):121-6.
In this study the long term effects of vasectomy on serum lipid profile, in vitro platelet aggregability and the risk of developing acute myocardial infarction have been elucidated in a monkey model. Four groups were made viz. (I) atherogenic diet fed vasectomised, (II) atherogenic diet fed control, (III) stock diet fed vasectomised and (IV) stock diet fed control. The respective diets were fed for first 6 months and then half of the atherogenic and stock diet fed monkeys were bilaterally vasectomised. The remaining monkeys were sham-vasectomised. At the end of one year, norepinephrine infusion was given to all the monkeys each day for 2 hrs, for 3 consecutive days and animals sacrificed after 96 hrs. Although serum lipids were not altered following vasectomy, platelet aggregation response was significantly enhanced in atherogenic diet fed animals. ECG changes were suggestive of acute myocardial ischaemia in 4 monkeys, 2 each from gp. I and II. Histopathology of heart revealed patchy myocardial necrosis and haemorrhage only in one monkey of gp. I, while others had fuchsinorrhagia indicating ischaemic change. These findings are in contrast to those seen in vasectomised human subjects.
在本研究中，已在猴模型中阐明了输精管切除术对血清脂质谱、体外血小板聚集性以及发生急性心肌梗死风险的长期影响。分为四组，即：（I）喂食致动脉粥样化饮食的输精管切除组，（II）喂食致动脉粥样化饮食的对照组，（III）喂食常规饮食的输精管切除组，以及（IV）喂食常规饮食的对照组。各自的饮食喂养6个月，然后对一半喂食致动脉粥样化饮食和常规饮食的猴子进行双侧输精管切除术。其余猴子进行假输精管切除术。在一年结束时，连续3天每天给所有猴子输注去甲肾上腺素2小时，96小时后处死动物。尽管输精管切除术后血清脂质未改变，但在喂食致动脉粥样化饮食的动物中血小板聚集反应显著增强。4只猴子的心电图变化提示急性心肌缺血，每组I和II各2只。心脏组织病理学显示，仅在组I的一只猴子中出现片状心肌坏死和出血，而其他猴子有品红出血，表明有缺血性改变。这些发现与输精管切除的人类受试者的情况相反。
