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初诊时表现为肱骨病理性骨折的滤泡状甲状腺癌。

Follicular thyroid carcinoma presenting with pathological fracture of the humerus at initial diagnosis.

作者信息

Yang Wanding, Cho WaiSum, Das Sudip, Conboy Peter

机构信息

Department of Otorhinolaryngology, Head and Neck Surgery, Leicester Royal Infirmary, Infirmary Square, LE1 5WW, UK

Department of Otorhinolaryngology, Head and Neck Surgery, Leicester Royal Infirmary, Infirmary Square, LE1 5WW, UK.

出版信息

J Surg Case Rep. 2017 Jan 19;2017(1):rjx002. doi: 10.1093/jscr/rjx002.

DOI:10.1093/jscr/rjx002
PMID:28108635
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5260851/
Abstract

Differentiated carcinomas of the thyroid gland usually have a good prognosis with prognosis often discussed in terms of 20 year survival. Nevertheless its 10-year-survival rate decreases when accompanied by distant metastasis. Follicular thyroid cancer (FTC) is the second most common thyroid cancer and usually presents with a solitary thyroid nodule with or without cervical lymphadenopathy. Distance metastasis at initial diagnosis is seldom observed with incidence range from 1 to 9%. In cases of bone metastasis, the incidence is only 2-3% and weight-bearing skeleton is preferentially affected. In our case, we present a patient with FTC that metastasized to the upper limb causing severe pain and pathological fracture at the initial presentation.

摘要

甲状腺分化型癌通常预后良好,其预后常以20年生存率来讨论。然而,当伴有远处转移时,其10年生存率会降低。滤泡状甲状腺癌(FTC)是第二常见的甲状腺癌,通常表现为单个甲状腺结节,伴有或不伴有颈部淋巴结病。初诊时很少观察到远处转移,发生率为1%至9%。在骨转移的病例中,发生率仅为2%至3%,负重骨骼更易受累。在我们的病例中,我们报告了一名患有FTC的患者,其在初次就诊时转移至上肢,导致严重疼痛和病理性骨折。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b185/5260851/67aad05e4f7d/rjx002f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b185/5260851/07ecd2dba4a3/rjx002f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b185/5260851/3ee2a693eb63/rjx002f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b185/5260851/67aad05e4f7d/rjx002f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b185/5260851/07ecd2dba4a3/rjx002f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b185/5260851/3ee2a693eb63/rjx002f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b185/5260851/67aad05e4f7d/rjx002f03.jpg

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本文引用的文献

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The underestimated risk of cancer in patients with multinodular goiters after a benign fine needle aspiration.良性细针穿刺后多结节性甲状腺肿患者被低估的癌症风险。
World J Surg. 2015 Mar;39(3):695-700. doi: 10.1007/s00268-014-2854-y.
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Clinical features of bone metastasis for differentiated thyroid carcinoma: A study of 21 patients from a Tunisian center.分化型甲状腺癌骨转移的临床特征:来自突尼斯一个中心的21例患者研究。
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Bone metastases from thyroid carcinoma: clinical characteristics and prognostic variables in one hundred forty-six patients.甲状腺癌骨转移:146例患者的临床特征及预后变量
Thyroid. 2000 Mar;10(3):261-8. doi: 10.1089/thy.2000.10.261.