Jiang Yongdong, Wu Hao, Liu Jing, Chen Yanbo, Xie Jingjing, Zhao Yashuang, Pang Da
Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.
Sino-Russian Medical Research Center, Heilongjiang Academy of Medical Sciences, Harbin, China.
Oncotarget. 2017 Feb 21;8(8):13932-13941. doi: 10.18632/oncotarget.14737.
Hyaluronic acid binding protein 1 (HABP1/p32/gC1qR) is overexpressed in breast cancer. However, it is unknown whether HABP1 gene polymorphisms affect breast cancer risk. This study aims to evaluate the potential association of single nucleotide polymorphisms (SNPs) of HABP1 with breast cancer in northern Chinese women.
The minor allele of rs2285747 was strongly associated with breast cancer with OR of 1.553 (95% CI = 1.251-1.927). SNP rs2285747 was also associated with high HABP1 protein expression under the co-dominant and dominant model (p = 0.005, p = 0.019, respectively). For rs2472614, the patients with CG and GG were more likely to have HER2 negative tumors compared to CC (p = 0.015). For rs3786054, the patients with AG and GG were more likely to have HER2 and P53 negative breast cancer compared to AA (p = 0.024, p = 0.064, receptively).
Seven SNPs were analyzed in 505 breast cancer patients and 505 controls using SNaPshot method. The associations between SNPs and breast cancer were examined by logistic regression. The associations of SNPs with HABP1 protein expression and disease characteristics were examined by chi-square test.
SNP rs2285747 of HABP1 increased breast cancer risk and elevated its protein expression in northern Chinese women.
透明质酸结合蛋白1（HABP1/p32/gC1qR）在乳腺癌中过表达。然而，HABP1基因多态性是否影响乳腺癌风险尚不清楚。本研究旨在评估中国北方女性中HABP1单核苷酸多态性（SNP）与乳腺癌的潜在关联。
rs2285747的次要等位基因与乳腺癌显著相关，比值比为1.553（95%置信区间=1.251-1.927）。在共显性和显性模型下，SNP rs2285747也与HABP1蛋白高表达相关（分别为p = 0.005，p = 0.019）。对于rs2472614，与CC基因型患者相比，CG和GG基因型患者更易发生HER2阴性肿瘤（p = 0.015）。对于rs3786054，与AA基因型患者相比，AG和GG基因型患者更易发生HER2和P53阴性乳腺癌（分别为p = 0.024，p = 0.064）。
采用SNaPshot方法对505例乳腺癌患者和505例对照进行7个SNP分析。通过逻辑回归检验SNP与乳腺癌之间的关联。通过卡方检验检验SNP与HABP1蛋白表达及疾病特征之间的关联。
HABP1的SNP rs2285747增加了中国北方女性患乳腺癌的风险并提高了其蛋白表达。
