Bahrami Afsane, Amerizadeh Forouzan, ShahidSales Soodabeh, Khazaei Majid, Ghayour-Mobarhan Majid, Sadeghnia Hamid Reza, Maftouh Mina, Hassanian Seyed Mahdi, Avan Amir
Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Cancer Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Cell Biochem. 2017 Aug;118(8):1979-1983. doi: 10.1002/jcb.25903. Epub 2017 Apr 25.
Wnt/β-catenin pathway is one of the main/frequent dysregulated pathways in several tumor types, including colon cancer. Aberrant activation of this pathway is associated with cell proliferation, invasive behaviors, and cell resistance, suggesting its potential value as a therapeutic target in treatment of CRC. Several agents have been developed for targeting of this pathway (e.g, natural agents: curcumin, 3,3-diindolylmethane, phytoestrogen; Synthetic/small Wnt inhibitors: Rofecoxib; PRI-724, CWP232291; and monoclonal antibody against frizzled receptors, Vanituctumab). This review summarizes the current knowledge about the therapeutic potential of targeting Wnt pathway with particular emphasis on preclinical/clinical studies in treatment of colorectal cancer. J. Cell. Biochem. 118: 1979-1983, 2017. © 2017 Wiley Periodicals, Inc.
Wnt/β-连环蛋白信号通路是包括结肠癌在内的多种肿瘤类型中主要/常见的失调信号通路之一。该信号通路的异常激活与细胞增殖、侵袭行为和细胞耐药性相关，提示其作为结直肠癌治疗靶点的潜在价值。已经开发了几种针对该信号通路的药物（例如，天然药物：姜黄素、3,3-二吲哚甲烷、植物雌激素；合成/小分子Wnt抑制剂：罗非昔布；PRI-724、CWP232291；以及抗卷曲受体单克隆抗体，凡尼妥单抗）。本综述总结了目前关于靶向Wnt信号通路治疗潜力的知识，特别强调了结直肠癌治疗的临床前/临床研究。《细胞生物化学杂志》118: 1979 - 1983, 2017。© 2017威利期刊公司
