Chida K, Sato A
Kekkaku. 1989 Oct;64(10):671-8.
The effects of aging and malnutrition on BAL cells, such as metabolic disorders and various immune responses, have been examined. In malnourished animals, the composition of phospholipids in BAL cells were changed, and the decrease in the number of specific prednisolone binding sites was recognized. Furthermore, the decrease of total cell counts and the population of lymphocytes, neutrophils and Ia-positive macrophages were observed in BAL cells. However, BAL cells obtained from heat-killed BCG sensitized animals in malnutrition preserved a good responsiveness. These impaired cellular development following starvation could be partly reversed by some antigenic factors, resulting in heavier cell infiltration and granuloma formation in the lung tissues. These observations suggest that alterations in immune responses accompanying malnutrition may be closely related to the mechanism of reactivation and the clinical course and profile of tuberculosis.
衰老和营养不良对支气管肺泡灌洗（BAL）细胞的影响，如代谢紊乱和各种免疫反应，已得到研究。在营养不良的动物中，BAL细胞中磷脂的组成发生了变化，并且发现特异性泼尼松龙结合位点的数量减少。此外，在BAL细胞中观察到总细胞计数以及淋巴细胞、中性粒细胞和Ia阳性巨噬细胞数量的减少。然而，从营养不良的热灭活卡介苗致敏动物中获得的BAL细胞保留了良好的反应性。饥饿后这些受损的细胞发育可被一些抗原因素部分逆转，导致肺组织中细胞浸润加重和肉芽肿形成。这些观察结果表明，营养不良伴随的免疫反应改变可能与结核病的再激活机制以及临床病程和特征密切相关。
