Lv Dongling, Cheng Xiaohu, Tang Lingyi, Jiang Meng
Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210009, China.
Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210009, China,.
Biomed Pharmacother. 2017 Apr;88:277-284. doi: 10.1016/j.biopha.2017.01.060. Epub 2017 Jan 19.
The flowers of Abelmoschus manihot (L.) Medic is a traditional Chinese medicine used for the treatment of ischemic diseases. The present study is to investigate whether total flavones (TA) of extracted from Abelmoschus manihot L. Medic has the potential cardioprotective effect on myocardial ischemia/reperfusion (I/R) damage in rats. The index of myocardial injury, inflammatory biomarkers and NLRP3-related parameters were measured, respectively. The results demonstrated that compared to I/R group, TA reduced myocardial infarction area, declined serum creatinine kinase (CK), lactate dehydrogenase (LDH) levels, attenuated serum interleukin-6 (IL-6), IL-1β and tumour necrosis factor (TNF-α) production. Moreover, TA markedly enhanced the activities of superoxide dismutase (SOD) and reduced the amounts of malondialdehyde (MDA) in I/R rats. In addition, TA reduced myocardial I/R induced injury in rats by inhibiting NLRPR3 inflammasome. Thus, it is assumed that TA could significantly improve myocardial I/R injury in rats partially through suppressing NLRP3 activtion.
黄蜀葵花是一种用于治疗缺血性疾病的传统中药。本研究旨在探讨从黄蜀葵中提取的总黄酮（TA）对大鼠心肌缺血/再灌注（I/R）损伤是否具有潜在的心脏保护作用。分别测定了心肌损伤指标、炎症生物标志物和NLRP3相关参数。结果表明，与I/R组相比，TA减小了心肌梗死面积，降低了血清肌酸激酶（CK）、乳酸脱氢酶（LDH）水平，减轻了血清白细胞介素-6（IL-6）、IL-1β和肿瘤坏死因子（TNF-α）的产生。此外，TA显著增强了I/R大鼠超氧化物歧化酶（SOD）的活性并减少了丙二醛（MDA）的含量。另外，TA通过抑制NLRPR3炎性小体减轻大鼠心肌I/R诱导的损伤。因此，推测TA可能部分通过抑制NLRP3激活而显著改善大鼠心肌I/R损伤。
