Gottumukkala Sujana, Tumati Vasu, Hrycushko Brian, Folkert Michael
Department of Radiation Oncology, Simmons Comprehensive Cancer Center at the University of Texas Southwestern Medical Center, Dallas, TX, USA.
Department of Medical Physics and Engineering, Simmons Comprehensive Cancer Center at the University of Texas Southwestern Medical Center, Dallas, TX, USA.
Curr Oncol Rep. 2017 Jan;19(1):2. doi: 10.1007/s11912-017-0561-1.
Radiation therapy is an integral component in the multimodality management of many gastrointestinal (GI) cancers at all stages of clinical presentation. With recent advances in technology and radiation delivery, external beam radiation therapy (EBRT) can be delivered with reduced toxicity. However, despite these advances, EBRT doses are still limited by the presence of radiosensitive serial structures near clinical targets in the GI tract. Relative to EBRT techniques, brachytherapy techniques have a lower integral dose and more rapid fall-off, allowing for high-dose delivery with little normal tissue exposure. Given the unique characteristics of brachytherapy, it is an attractive strategy to treat GI malignancies. This review addresses the application of both high-dose rate brachytherapy (HDRBT) and low-dose rate brachytherapy (LDRBT) to multiple GI malignancies for both definitive and palliative management.
放射治疗是许多胃肠道（GI）癌症在临床各阶段多模式管理中不可或缺的组成部分。随着技术和放射治疗的最新进展，外照射放射治疗（EBRT）的毒性可以降低。然而，尽管有这些进展，EBRT剂量仍受胃肠道临床靶区附近放射敏感串联结构的限制。相对于EBRT技术，近距离放射治疗技术的总体剂量较低且剂量下降更快，能够在很少暴露正常组织的情况下进行高剂量照射。鉴于近距离放射治疗的独特特性，它是治疗胃肠道恶性肿瘤的一种有吸引力的策略。本综述探讨了高剂量率近距离放射治疗（HDRBT）和低剂量率近距离放射治疗（LDRBT）在多种胃肠道恶性肿瘤的根治性和姑息性治疗中的应用。
