Hoffmann Rüdiger, Kessler David-Emanuel, Weiss Jakob, Clasen Stephan, Pereira Philippe L, Nikolaou Konstantin, Rempp Hansjörg
a Department of Diagnostic and Interventional Radiology , Eberhard Karls University Tuebingen , Tuebingen , Germany.
b Department of Radiology, Minimally Invasive Therapies and Nuclear Medicine, SLK-Kliniken Heilbronn GmbH , Heilbronn , Germany.
Int J Hyperthermia. 2017 Sep;33(6):617-623. doi: 10.1080/02656736.2017.1284349. Epub 2017 Mar 12.
Evaluation of a newly developed MR-compatible microwave ablation system with focus on ablation performance and comparison with a corresponding standard microwave ablation system.
A total of 52 ablations were performed with a non-cooled microwave ablation system in an ex vivo bovine liver model using the following settings: [A] 16G-standard antenna, 2 cm active tip, 2.4 m cable; [B] MR-compatible 16G-antenna, 2 cm active tip, 2.4 m cable; [C] MR-compatible 16G-antenna, 2 cm active tip, extended 6 m cable; and [D] MR-compatible 16G-antenna, 4 cm active tip, extended 6 m cable. Ablation durations were 3, 5 and 10 min, and additionally 15 min for [D]. Ablations zones were measured for short-axis diameter (SA) and long-axis diameter (LA). Settings [A]-[C] were compared regarding SA, volume (V) and generator energy output (E) with analysis of variance and Tukey-Kramer post hoc test. Ablation performance of the MR-compatible settings [C] and [D] were compared regarding SA, V, E and sphericity index (SA/LA) with unpaired t-test. p < 0.05 was considered as statistically significant.
No significant differences were found between [A], [B] and [C] regarding SA and V (10 min; SA[A] = 25.8 ± 2.4 mm, SA[B] = 25.3 ± 1.9 mm, SA[C] = 25.0 ± 2.0 mm, p = 0.88; V[A] = 17.8 ± 4.4 cm³, V[B] = 16.6 ± 3.0 cm³, V[C] = 17.8 ± 2.7 cm³, p = 0.85); however, the highest energy output was measured for setting [C] (10 min; [A]: 9.9 ± 0.5 kJ, [B]: 10.1 ± 0.5 kJ, [C]: 13.1 ± 0.3 kJ, p < 0.001). SA, V and E were significantly larger with setting [D] than [C] with 10 min ablations (SA[C] = 25.0 ± 2.0 mm, SA[D] = 34.0 ± 2.9 mm, p = 0.003; V[C] = 17.8 ± 2.7 cm³, V[D] = 39.4 ± 7.5 cm³, p = 0.007; E[C] = 13.1 ± 0.3 kJ, E[D] = 16.7 ± 0.8 kJ, p = 0.002) without significant difference in sphericity index (SA/LA[C] = 0.46 ± 0.02, SA/LA[D] = 0.52 ± 0.04, p = 0.08).
The tested MR-compatible system can be used without loss of ablation performance compared to the standard system.
评估一种新开发的与磁共振兼容的微波消融系统，重点关注消融性能，并与相应的标准微波消融系统进行比较。
在离体牛肝模型中，使用以下设置，通过非冷却微波消融系统共进行了52次消融：[A]16G标准天线，2厘米有效尖端，2.4米电缆；[B]与磁共振兼容的16G天线，2厘米有效尖端，2.4米电缆；[C]与磁共振兼容的16G天线，2厘米有效尖端，延长至6米电缆；以及[D]与磁共振兼容的16G天线，4厘米有效尖端，延长至6米电缆。消融持续时间为3、5和10分钟，[D]组额外为15分钟。测量消融区的短轴直径（SA）和长轴直径（LA）。对设置[A]-[C]的SA、体积（V）和发生器能量输出（E）进行方差分析和Tukey-Kramer事后检验比较。对与磁共振兼容的设置[C]和[D]的SA、V、E和球形指数（SA/LA）进行不成对t检验比较。p<0.05被认为具有统计学意义。
在10分钟时，设置[A]、[B]和[C]在SA和V方面未发现显著差异（SA[A]=25.8±2.4毫米，SA[B]=25.3±1.9毫米，SA[C]=25.0±2.0毫米，p=0.88；V[A]=17.8±4.4立方厘米，V[B]=16.6±3.0立方厘米，V[C]=17.8±2.7立方厘米，p=0.85）；然而，设置[C]的能量输出最高（10分钟时；[A]：9.9±0.5千焦，[B]：10.1±0.5千焦，[C]：13.1±0.3千焦，p<0.001）。在10分钟消融时，设置[D]的SA、V和E显著大于[C]（SA[C]=25.0±2.0毫米，SA[D]=34.0±2.9毫米，p=0.003；V[C]=17.8±2.7立方厘米，V[D]=39.4±7.5立方厘米，p=0.007；E[C]=13.1±0.3千焦，E[D]=16.7±0.8千焦，p=0.002），球形指数无显著差异（SA/LA[C]=0.46±0.02，SA/LA[D]=0.52±0.04，p=0.08）。
与标准系统相比，经测试的与磁共振兼容的系统在使用时不会损失消融性能。
