Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Jinan, Shandong Province, China No. 16766, Jingshi Road, Jinan, Shandong Province, China.
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital and Research Institute, Beijing, China.
J Cancer Res Ther. 2022 Dec;18(7):1876-1883. doi: 10.4103/jcrt.jcrt_1124_22.
Percutaneous image-guided thermal ablation has an increasing role in the treatment of primary and metastatic lung tumors. Although microwave ablation (MWA) has emerged advantageous as a new ablation technology, more research is needed to improve it. This study aims to investigate the ablation zone of three microwave antennas in ex vivo porcine lung.
In the ex vivo standard model and porcine lung model, MWA was performed in three power output settings (50 W, 60 W, and 70 W) for 3, 6, 9, and 12 min using three microwave antennas, with outer diameter of 1.03 mm (19G), 1.6 mm (16G), and 2.0 mm (14G). A total of 108 and 216 sessions were performed (3 or 6 sessions per time setting with the 14G, 16G, and 19G microwave antennas). After the MWA was complete, we evaluated the shape and extent of the coagulation zone and measured the maximum long-axis (along the needle axis; length [L]) and maximum short-axis (perpendicular to the needle; diameter [D]) of the ablation zones using a ruler; subsequently, the sphericity index (L/D) was calculated. The sphericity index can be simplified as long-axis/short-axis.
In the ex vivo standard model study, the long- and short-axis diameters and sphericity indices were not statistically different between the 14G, 16G, and 19G groups. In the ex vivo porcine lung study, the long- and short-axis diameters did not differ statistically between the 14G, 16G, and 19G groups (P < 0.05 each). The sphericity index for the 19G microwave antenna was higher than the sphericity indices for the 14G and 16G microwave antennas (P < 0.05); however, the index for the 14G microwave antenna was not statistically different than that for the 16G microwave antenna (P > 0.05).
The ablation zone of the 19G antenna was the same as those of the 14G and 16G antennas in vitro. Thus, the 19G antenna may reduce the incidence of complications in lung tumor ablation.
经皮影像引导热消融在原发性和转移性肺肿瘤的治疗中发挥着越来越重要的作用。虽然微波消融（MWA）作为一种新的消融技术已经显现出优势，但仍需要更多的研究来改进它。本研究旨在探讨三种微波天线在离体猪肺中的消融区域。
在离体标准模型和猪肺模型中，使用三种外径分别为 1.03mm（19G）、1.6mm（16G）和 2.0mm（14G）的微波天线，在三种功率输出设置（50W、60W 和 70W）下，分别进行 3、6、9 和 12 分钟的 MWA。共进行了 108 和 216 次治疗（每个时间设置进行 3 或 6 次治疗，使用 14G、16G 和 19G 微波天线）。MWA 完成后，我们评估了凝固区域的形状和范围，并使用标尺测量了消融区域的最大长轴（沿针轴；长度[L]）和最大短轴（垂直于针；直径[D]）；随后计算了球形指数（L/D）。球形指数可简化为长轴/短轴。
在离体标准模型研究中，14G、16G 和 19G 组之间的长轴和短轴直径以及球形指数没有统计学差异。在离体猪肺研究中，14G、16G 和 19G 组之间的长轴和短轴直径没有统计学差异（P<0.05 各）。19G 微波天线的球形指数高于 14G 和 16G 微波天线的球形指数（P<0.05）；然而，14G 微波天线的指数与 16G 微波天线的指数没有统计学差异（P>0.05）。
19G 天线的消融区域与体外的 14G 和 16G 天线相同。因此，19G 天线可能会降低肺肿瘤消融并发症的发生率。
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