de Temple R, Brien G, Hellmann C, Otting U, Schöpke W, Schönberger B
Kinderarztl Prax. 1989 Sep;57(9):435-42.
Basic ideas about the pathogenesis of cystinuria and calculi formation are shown in this case report. Aspects of a present and effective cystine stone therapy are discussed after that. We present the therapeutic procedure in two patients with recurrent cystine urinary stone formation who were operated on cystine stones in the past. Our experiences with a combination of chemolitholysis with N-acetyl-cystein through percutaneous nephrostomy and an oral drug therapy with alpha-mercaptopropionyl-glycin are reported. This form of treatment was successful in our two cases. A metaphylactic therapy is necessary to prevent recurrent cystine stone formation.
本病例报告展示了胱氨酸尿症发病机制及结石形成的基本观点。之后讨论了当前有效的胱氨酸结石治疗方法。我们介绍了两名既往因胱氨酸尿结石接受手术的复发性胱氨酸尿结石形成患者的治疗过程。报告了我们通过经皮肾造瘘进行N - 乙酰 - 半胱氨酸化学溶石与α - 巯基丙酰甘氨酸口服药物治疗相结合的经验。这种治疗形式在我们的两个病例中取得了成功。预防复发性胱氨酸结石形成需要进行预防性治疗。
