[用N-乙酰半胱氨酸溶解胱氨酸结石]
[The dissolution of cystine lithiasis with n-acetylcysteine].
作者信息
Benítez Navio J, Tudela Pavón P, Laguna Urraca G, Casanueva Luis T, Ruana Encinar M, Mata Guijarro F, Gallardo Galán C
机构信息
Servicio de Urología, Hospital Na. Sra. Alarcos, Ciudad Real, España.
出版信息
Arch Esp Urol. 1995 Nov;48(9):944-8.
OBJECTIVE
The results of in situ dissolution of a cystine calculus is described. This approach was attempted in a female patient for whom surgery was not considered to be the best therapeutic option.
METHODS
An obstructive cystine calculus was treated by in situ litholysis using N-acetylcysteine applied locally via two percutaneous nephrostomies and adjuvant oral metaphylaxis. The patient had a long clinical history of lithiasis that had also required surgery and a family history of cystinuria.
RESULTS
In situ litholysis completely dissolved the cystine calculus and avoided the need for a complex surgery. The procedure and a pharmacological analysis are presented.
CONCLUSIONS
In our view, this procedure is practical, carries minimal morbidity and should be considered in the management of cystine calculus.
目的
描述胱氨酸结石原位溶解的结果。一名女性患者被认为手术并非最佳治疗选择，遂尝试了这种方法。
方法
通过经皮肾造瘘术局部应用N-乙酰半胱氨酸进行原位溶石治疗阻塞性胱氨酸结石，并辅以口服预防性药物。该患者有长期的结石病史，此前也曾接受过手术治疗，且有胱氨酸尿症家族史。
结果
原位溶石完全溶解了胱氨酸结石，避免了复杂的手术。介绍了该手术过程及药理学分析。
结论
我们认为，该手术切实可行，发病率极低，在胱氨酸结石的治疗中应予以考虑。
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