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碳离子治疗中用于在线束流射程监测的新型跟踪装置设计

Design of a new tracking device for on-line beam range monitor in carbon therapy.

作者信息

Traini Giacomo, Battistoni Giuseppe, Bollella Angela, Collamati Francesco, De Lucia Erika, Faccini Riccardo, Ferroni Fernando, Frallicciardi Paola Maria, Mancini-Terracciano Carlo, Marafini Michela, Mattei Ilaria, Miraglia Federico, Muraro Silvia, Paramatti Riccardo, Piersanti Luca, Pinci Davide, Rucinski Antoni, Russomando Andrea, Sarti Alessio, Sciubba Adalberto, Senzacqua Martina, Solfaroli-Camillocci Elena, Toppi Marco, Voena Cecilia, Patera Vincenzo

机构信息

Dipartimento di Fisica, Sapienza Università di Roma, Pl.e Aldo Moro 2, 00185 Roma, Italy; INFN Sezione di Roma, Pl.e Aldo Moro 2, 00185 Roma, Italy.

INFN Sezione di Milano, Via Celoria 16, 20133 Milano, Italy.

出版信息

Phys Med. 2017 Feb;34:18-27. doi: 10.1016/j.ejmp.2017.01.004. Epub 2017 Jan 19.

Abstract

Charged particle therapy is a technique for cancer treatment that exploits hadron beams, mostly protons and carbon ions. A critical issue is the monitoring of the beam range so to check the correct dose deposition to the tumor and surrounding tissues. The design of a new tracking device for beam range real-time monitoring in pencil beam carbon ion therapy is presented. The proposed device tracks secondary charged particles produced by beam interactions in the patient tissue and exploits the correlation of the charged particle emission profile with the spatial dose deposition and the Bragg peak position. The detector, currently under construction, uses the information provided by 12 layers of scintillating fibers followed by a plastic scintillator and a pixelated Lutetium Fine Silicate (LFS) crystal calorimeter. An algorithm to account and correct for emission profile distortion due to charged secondaries absorption inside the patient tissue is also proposed. Finally detector reconstruction efficiency for charged particle emission profile is evaluated using a Monte Carlo simulation considering a quasi-realistic case of a non-homogenous phantom.

摘要

带电粒子疗法是一种利用强子束(主要是质子和碳离子)进行癌症治疗的技术。一个关键问题是监测束流射程,以便检查对肿瘤和周围组织的剂量沉积是否正确。本文介绍了一种用于笔形束碳离子疗法中束流射程实时监测的新型跟踪装置的设计。该装置跟踪患者组织中束流相互作用产生的次级带电粒子,并利用带电粒子发射轮廓与空间剂量沉积和布拉格峰位置之间的相关性。目前正在建造的探测器使用由12层闪烁光纤提供的信息,随后是一个塑料闪烁体和一个像素化的硅酸镥(LFS)晶体量热计。还提出了一种算法,用于考虑并校正由于患者组织内部带电次级粒子吸收而导致的发射轮廓畸变。最后,使用蒙特卡罗模拟,考虑非均匀体模的准实际情况,评估了探测器对带电粒子发射轮廓的重建效率。

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