Soto-Gamez Abel, Demaria Marco
University of Groningen, European Institute for the Biology of Aging (ERIBA), University Medical Center Groningen (UMCG), Groningen, The Netherlands.
University of Groningen, European Institute for the Biology of Aging (ERIBA), University Medical Center Groningen (UMCG), Groningen, The Netherlands.
Drug Discov Today. 2017 May;22(5):786-795. doi: 10.1016/j.drudis.2017.01.004. Epub 2017 Jan 19.
Organismal aging is a multifactorial process characterized by the onset of degenerative conditions and cancer. One of the key drivers of aging is cellular senescence, a state of irreversible growth arrest induced by many pro-tumorigenic stresses. Senescent cells accumulate late in life and at sites of age-related pathologies, where they contribute to disease onset and progression through complex cell and non-cell autonomous effects. Here, we summarize the mechanisms by which cellular senescence can promote aging, and we offer an extensive description of current potential pharmacological interventions for senescent cells, highlighting limitations and suggesting alternatives.
机体衰老 是一个多因素过程，其特征为退行性疾病和癌症的发生。衰老的关键驱动因素之一是细胞衰老，这是一种由多种促肿瘤应激诱导的不可逆生长停滞状态。衰老细胞在生命后期以及与年龄相关的病理部位积累，在这些部位，它们通过复杂的细胞和非细胞自主效应促进疾病的发生和发展。在这里，我们总结了细胞衰老促进衰老的机制，并对目前针对衰老细胞的潜在药物干预进行了广泛描述，强调了局限性并提出了替代方案。
