AQP3 和 AQP10 在皮肤中的过度表达加剧了银屑病样棘层肥厚。
Overexpression of AQP3 and AQP10 in the skin exacerbates psoriasiform acanthosis.
机构信息
Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA.
Murdough Family Center for Psoriasis, University Hospitals Case Medical Center, Cleveland, OH, USA.
出版信息
Exp Dermatol. 2017 Oct;26(10):949-951. doi: 10.1111/exd.13307. Epub 2017 Apr 21.
Abstract
We previously observed that aquaporin-3 and aquaporin-10 are upregulated in the epidermis of hand dermatitis patients (Med. Hypotheses, 84, 2015, 498). To address the functional relevance of this upregulation, we overexpressed AQP3/AQP10 in mice using the human K1 promoter. Combining imiquimod with detergent-containing water challenge, a common trigger in hand and other dermatitis, resulted in an increase in acanthosis in mice overexpressing AQP3 or AQP3 and AQP10. Aquaporin overexpression also drove a trend towards greater weight loss in these animals. These data support a role for cutaneous aquaporins in the pathogenesis of dermatitis and as a potential target in their treatment.
摘要
我们之前观察到手部皮炎患者的表皮中水通道蛋白-3 和水通道蛋白-10 上调（医学假说，84，2015，498）。为了研究这种上调的功能相关性，我们使用人 K1 启动子在小鼠中过表达 AQP3/AQP10。将咪喹莫特与含有洗涤剂的水挑战（手部和其他皮炎的常见诱因）联合使用，导致过表达 AQP3 或 AQP3 和 AQP10 的小鼠棘层肥厚增加。水通道蛋白过表达也导致这些动物体重下降的趋势更大。这些数据支持皮肤水通道蛋白在皮炎发病机制中的作用，并作为其治疗的潜在靶点。
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